Meta-Analysis
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 6, 2022; 10(7): 2194-2205
Published online Mar 6, 2022. doi: 10.12998/wjcc.v10.i7.2194
Prognostic value of neutrophil/lymphocyte, platelet/lymphocyte, lymphocyte/monocyte ratios and Glasgow prognostic score in osteosarcoma: A meta-analysis
Li-Peng Peng, Jie Li, Xian-Feng Li
Li-Peng Peng, Jie Li, Xian-Feng Li, Department of Orthopedic, The Second People's Hospital of Yibin, Yibin 644000, Sichuan Province, China
Author contributions: Li XF made the substantial contributions to the conception and design of the work; Peng LP and Li J searched, selected materials and extracted data; Peng LP wrote this manuscript; Li J and Li XF revised the paper carefully and also contributed to the statistical analysis; all authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
PRISMA 2009 Checklist statement: This systematic review and meta-analysis were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xian-Feng Li, MD, Surgeon, Department of Orthopedic, The Second People's Hospital of Yibin, No. 96 North Street, Cuiping District, Yibin 64000, Sichuan Province, China. 2396806953@qq.com
Received: October 4, 2021
Peer-review started: October 4, 2021
First decision: November 11, 2021
Revised: November 19, 2021
Accepted: January 17, 2022
Article in press: January 17, 2022
Published online: March 6, 2022
Processing time: 148 Days and 20.2 Hours
Abstract
BACKGROUND

Some studies investigated the prognostic role of several blood biomarkers, including the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), lymphocyte/monocyte ratio (LMR) and Glasgow prognostic score (GPS), in osteosarcoma, but their results were inconsistent with each other.

AIM

To identify the prognostic value of NLR, PLR, LMR and GPS in osteosarcoma patients through reviewing relevant studies.

METHODS

The PubMed, EMBASE, Web of Science and CNKI databases were searched up to October 2, 2021. The primary and second outcomes were overall survival (OS) and disease-free survival (DFS), respectively. The hazard ratios (HRs) with 95% confidence intervals (CIs) were combined to assess the association between these indicators and prognosis of osteosarcoma patients.

RESULTS

A total of 13 studies involving 2087 patients were eventually included. The pooled results demonstrated that higher NLR and GPS were significantly associated with poorer OS (HR = 1.88, 95%CI: 1.38-2.55, P < 0.001; HR = 2.19, 95%CI: 1.64-2.94, P < 0.001) and DFS (HR = 1.67, 95%CI: 1.37-2.04, P < 0.001; HR = 2.50, 95%CI: 1.39-4.48, P < 0.001). However, no significant relationship of PLR and LMR and OS (P = 0.085; P = 0.338) and DFS (P = 0.396; P = 0.124) was observed.

CONCLUSION

Higher NLR and GPS were related with worse prognosis and might serve as novel prognostic indicators for osteosarcoma patients.

Keywords: Neutrophil/lymphocyte; Platelet/lymphocyte; Lymphocyte/monocyte ratios; Glasgow prognostic score; Osteosarcoma; Prognosis; Meta-analysis

Core Tip: Higher neutrophil/lymphocyte ratio (NLR) and Glasgow prognostic score (GPS) were significantly associated with poorer overall survival (OS) (P < 0.001; P < 0.001) and disease-free survival (DFS) (P < 0.001; P < 0.001). However, no significant relationship of platelet/lymphocyte ratio and lymphocyte/monocyte ratio and OS (P = 0.085; P = 0.338) and DFS (P = 0.396; P = 0.124) was observed. Higher NLR and GPS were related with worse prognosis in osteosarcoma and might serve as reliable and valuable prognostic indicators for osteosarcoma patients.