Xie FF, Zhang YF, Hu YF, Xie YY, Wang XY, Wang SZ, Xie BQ. Significance of serum glucagon-like peptide-1 and matrix Gla protein levels in patients with diabetes and osteoporosis. World J Clin Cases 2022; 10(5): 1527-1535 [PMID: 35211590 DOI: 10.12998/wjcc.v10.i5.1527]
Corresponding Author of This Article
Bao-Qiang Xie, BM BCh, Chief Doctor, Department of Endocrinology, Guangdong Provincial People's Hospital Ganzhou Hospital (Ganzhou Municipal Hospital), No. 49 Dagong Road, Zhanggong District, Ganzhou 341000, Jiangxi Province, China. xiebaoqiang1629@163.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Fei-Fei Xie, Yu-Fang Zhang, Yan-Fang Hu, Yun-Yun Xie, Xiao-Ying Wang, Shu-Zhen Wang, Bao-Qiang Xie, Department of Endocrinology, Guangdong Provincial People’s Hospital Ganzhou Hospital (Ganzhou Municipal Hospital), Ganzhou 341000, Jiangxi Province, China
Author contributions: Xie FF and Zhang YF designed the experiment; Hu YF drafted the work; Xie YY, Wang XY, and Wang SZ collected the data; Xie BQ and Xie FF analyzed and interpreted the data; and Zhang YF, Hu YF, and Xie YY wrote the article.
Supported byJiangxi Provincial Health and Family Planning Commission “Science and Technology Plan”.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Guangdong Provincial People’s Hospital Ganzhou Hospital.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: No conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Received: November 14, 2021 Peer-review started: November 14, 2021 First decision: December 9, 2021 Revised: December 27, 2021 Accepted: January 11, 2022 Article in press: January 11, 2022 Published online: February 16, 2022 Processing time: 88 Days and 21.4 Hours
Core Tip
Core Tip: Serum glucagon-like peptide-1 (GLP-1) and matrix Gla protein (MGP)levels were significantly positively correlated with bone mineral density values of the hip joint and lumbar vertebrae. They were significantly negatively correlated with type 1 procollagen amino-terminal propeptide, osteocalcin, and special sequence of carboxy-terminal peptide β of type 1 collagen. Older age and duration of diabetes were independent risk factors for osteoporosis for diabetic patients. Increased GLP-1 and MGP levels were protective factors against osteoporosis for diabetic patients. GLP-1 and MGP levels should be used as auxiliary evaluation indexes to evaluate the risk of osteoporosis for patients with diabetes to enable early detection of and intervention for diabetes with osteoporosis and improve its prognosis.
