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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 16, 2022; 10(5): 1457-1472
Published online Feb 16, 2022. doi: 10.12998/wjcc.v10.i5.1457
Published online Feb 16, 2022. doi: 10.12998/wjcc.v10.i5.1457
Nonalcoholic fatty liver disease shows significant sex dimorphism
Xing-Yu Chen, Cong Wang, Yi-Zhou Huang, Li-Li Zhang, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 404100, China
Author contributions: Chen XY was the main author of the review, and completed the collection and analysis of relevant literature and the writing of the first draft of the paper; Wang C and Huang YZ participated in the analysis and collation of literature materials; Zhang LL is the principal of the project, supervising the thesis writing; all authors have read and approve the final manuscript.
Conflict-of-interest statement: The authors declare no conflicts of interest associated with this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Li Zhang, MD, PhD, Associate Professor, Doctor, Postdoc, Research Fellow, The Second Affiliated Hospital, Chongqing Medical University, No. 74 Linjiang Road, Yuzhong District, Chongqing 404100, China. zhanglili.jl@foxmail.com
Received: October 5, 2021
Peer-review started: October 5, 2021
First decision: November 15, 2021
Revised: December 2, 2021
Accepted: December 31, 2021
Article in press: December 31, 2021
Published online: February 16, 2022
Peer-review started: October 5, 2021
First decision: November 15, 2021
Revised: December 2, 2021
Accepted: December 31, 2021
Article in press: December 31, 2021
Published online: February 16, 2022
Core Tip
Core Tip: Nonalcoholic fatty liver disease (NAFLD) is a sexual dimorphic disease, and its prevalence worldwide is increasing each year. However, our understanding of sex differences in NAFLD remains insufficient. The incidence in males is significantly higher than that in females, and studies have also revealed significant sex differences in influencing factors, pathophysiology, complications and therapies. This review summarizes the current research progress on sex differences in NAFLD and indicates that whether sex differences in NAFLD can be considered in future research, treatment and prevention is worth exploring.