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World J Clin Cases. Dec 16, 2022; 10(35): 12875-12879
Published online Dec 16, 2022. doi: 10.12998/wjcc.v10.i35.12875
Real role of growth factor receptor-binding protein 10: Linking lipid metabolism to diabetes cardiovascular complications
Yang Yang, Hua-Jie Yao, Wei-Jie Lin, Si-Chao Huang, Xiao-Dong Li, Fa-Zhong He
Yang Yang, Wei-Jie Lin, Si-Chao Huang, Department of Pharmacy, Zhuhai People’s Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai 519000, Guangdong Province, China
Hua-Jie Yao, College of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430000, Hubei Province, China
Xiao-Dong Li, Fa-Zhong He, Department of Quality Control, Zhuhai People’s Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai 519000, Guangdong Province, China
Author contributions: Yang Y performed the majority of the writing, prepared the figures; Yao HJ coordinated the writing of the paper; Lin WJ and Huang SC contributed to the design of this work, and performed overall supervision; He FZ and Li XD revised the paper, and make equal contributions; and all authors approved the final manuscript.
Supported by Zhuhai People’s Hospital (Zhuhai Hospital Affiliated with Jinan University) Cultivation Project, No. 2009PY-09; National Scientific Foundation of China, No. 81903715.
Conflict-of-interest statement: All authors declare that there are no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fa-Zhong He, PhD, Pharmacist, Department of Quality Control, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), No. 79 Kangning Road, Zhuhai 519000, Guangdong Province, China. fazhong2006@ext.jnu.edu.cn
Received: September 20, 2022
Peer-review started: September 20, 2022
First decision: October 21, 2022
Revised: November 13, 2022
Accepted: November 17, 2022
Article in press: November 17, 2022
Published online: December 16, 2022
Processing time: 85 Days and 0.6 Hours
Core Tip

Core Tip: Growth factor receptor-binding protein 10 (GRB10) performs a vital role in vascular complications of type 2 diabetes mellitus (T2DM). GRB10 variant may be associated with the blood lipids and then may also related to the risk of coronary heart disease in patients with T2DM. GRB10 is expected to be a potential target for the prevention and treatment of vascular complications in patients with T2DM.