Minireviews
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 6, 2022; 10(31): 11283-11291
Published online Nov 6, 2022. doi: 10.12998/wjcc.v10.i31.11283
Role of nickel-regulated small RNA in modulation of Helicobacter pylori virulence factors
Fabrício Freire de Melo, Hanna Santos Marques, Fabian Fellipe Bueno Lemos, Marcel Silva Luz, Samuel Luca Rocha Pinheiro, Lorena Sousa de Carvalho, Cláudio Lima Souza, Márcio Vasconcelos Oliveira
Fabrício Freire de Melo, Fabian Fellipe Bueno Lemos, Marcel Silva Luz, Samuel Luca Rocha Pinheiro, Lorena Sousa de Carvalho, Cláudio Lima Souza, Márcio Vasconcelos Oliveira, Institution Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista 45029-094, Brazil
Hanna Santos Marques, Campus Vitória da Conquista, Universidade Estadual do Sudoeste da Bahia, Vitória da Conquista 45083-900, Brazil
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, manuscript drafting, critical revision, and editing, and approval of the final version; all authors agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Supported by CNPq Brazil (National Council for Scientific and Technological Development) - FFM, No. 317005/2021-09.
Conflict-of-interest statement: All authors declare no potential conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fabrício Freire de Melo, PhD, Professor, Institution Multidisciplinar em Saúde, Universidade Federal da Bahia, Rua Horminio Barros 58, Vitória da Conquista 45029-094, Brazil. freiremeloufba@gmail.com
Received: July 7, 2022
Peer-review started: July 7, 2022
First decision: July 31, 2022
Revised: August 14, 2022
Accepted: September 6, 2022
Article in press: September 6, 2022
Published online: November 6, 2022
Processing time: 112 Days and 3.7 Hours
Core Tip

Core Tip: This paper aims to review current information about the role of nickel-regulated small RNA (NikS) in the modulation of main Helicobacter pylori virulence factors, specially cytotoxin associated antigen A (CagA), which is crucial to gastric cancer development. Here we explore what is the most important about the epigenetic processes involved in the interaction between nickel levels, NikS, and CagA and their potential clinical repercussions.