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World J Clin Cases. Oct 26, 2022; 10(30): 10823-10839
Published online Oct 26, 2022. doi: 10.12998/wjcc.v10.i30.10823
New insights into the interplay between intestinal flora and bile acids in inflammatory bowel disease
Lie Zheng
Lie Zheng, Department of Gastroenterology, Shaanxi Hospital of Traditional Chinese Medicine, Xi’an 710003, Shaanxi Province, China
Author contributions: Zheng L reviewed the literature, prepared the manuscript, performed to the writing, revising of the manuscript, contributed to design this work, and performed overall supervision, wrote and revised the paper, approved the final manuscript.
Supported by General Research of Xi’an Science and Technology Planning Project, No. 2022JH-YBYJ-0265; Shaanxi Province Natural Science Basic Research Program-General Project, No. 2019JM-580; Project of Shaanxi Administration of Traditional Chinese Medicine, No. 2019-ZZ-JC010; and Shaanxi Provincial Hospital of Traditional Chinese Medicine, No. 2021-07 and No. 2018-04.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lie Zheng, PhD, Department of Gastroenterology, Shaanxi Hospital of Traditional Chinese Medicine, No. 4 Xihuamen, Xi’an 710003, Shaanxi Province, China. 492688049@qq.com
Received: April 18, 2022
Peer-review started: April 18, 2022
First decision: June 2, 2022
Revised: June 8, 2022
Accepted: September 16, 2022
Article in press: September 16, 2022
Published online: October 26, 2022
Processing time: 185 Days and 13.8 Hours
Core Tip

Core Tip: With the increase of economic level and the improvement of people's living standard, the incidence of inflammatory bowel disease (IBD) in China is gradually increasing, causing a heavy burden to the society. The pathogenesis of IBD is related to genetics, environment, intestinal microecology and immunity, but the specific biological mechanism is still unclear. As an important part of intestinal microecology, intestinal flora can directly affect intestinal environmental homeostasis and participate in bile acid (BA) metabolism, while the abnormal BA metabolism also affects the quality and quantity of intestinal flora, and both of them are involved in the occurrence and development of intestinal inflammation.