Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 16, 2022; 10(29): 10779-10786
Published online Oct 16, 2022. doi: 10.12998/wjcc.v10.i29.10779
Secondary light chain amyloidosis with Waldenström’s macroglobulinemia and intermodal marginal zone lymphoma: A case report
Zhen-Yu Zhao, Nan Tang, Xiang-Jun Fu, Li-Er Lin
Zhen-Yu Zhao, Xiang-Jun Fu, Li-Er Lin, Department of Hematology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou 570311, Hainan Province, China
Nan Tang, Department of Emergency Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou 570311, Hainan Province, China
Author contributions: Zhao ZY and Tang N gathered information and wrote the manuscript; Fu XJ performed the evaluation, diagnosis, and treatment; all authors approved the final contents of the manuscript.
Supported by Medical and Health Research Project of Hainan Province, No. 21A200197.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Er Lin, Doctor, Chief Physician, Department of Hematology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, No. 19 Xiuhua Road, Xiuying District, Haikou 570311, Hainan Province, China. linlier268@163.com
Received: July 12, 2022
Peer-review started: July 12, 2022
First decision: August 4, 2022
Revised: August 17, 2022
Accepted: September 4, 2022
Article in press: September 4, 2022
Published online: October 16, 2022
Processing time: 78 Days and 19.4 Hours
Core Tip

Core Tip: Waldenström's macroglobulinemia (WM) is a lymphoplasmacytic lymphoma, and internodal marginal zone lymphoma (INMZL) is another rare subtype of clinically inertial non-Hodgkin's lymphoma. We report a rare secondary light chain amyloidosis case due to WM and INMZL. We also retrieved related articles indexed in PubMed. Bortezomib-based therapy, including bortezomib, dexamethasone, and zanubrutinb, was administered for two months, and treatment efficacy was evaluated as partial remission. Treatment should be based on the patient's physiological age, life expectancy, and tolerance to treatment. Therefore, we recommend detailed clinical evaluation and active identification of the etiology to avoid missed diagnosis and misdiagnosis.