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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 16, 2022; 10(29): 10742-10754
Published online Oct 16, 2022. doi: 10.12998/wjcc.v10.i29.10742
Published online Oct 16, 2022. doi: 10.12998/wjcc.v10.i29.10742
Cutaneous allergic reaction to subcutaneous vitamin K1: A case report and review of literature
Miao Zhang, Chun-Xiao Wang, Nai-Xuan Lin, Xin Li, Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
Miao Zhang, Chun-Xiao Wang, Nai-Xuan Lin, Xin Li, Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai 201203, China
Jia Chen, Department of Dermatopathology, Shanghai Skin Disease Hospital, Tongji University, Shanghai 200443, China
Author contributions: Zhang M contributed to the manuscript writing and editing and the data collection; Chen J, Wang CX, and Lin NX contributed to the data analysis; Li X contributed to the study conceptualization and supervision; all authors have read and approved the final manuscript.
Informed consent statement: Written informed consent was obtained from the patient for the publication of this case and accompanying images.
Conflict-of-interest statement: The authors declare no conflicts of interest related to the publication of this report.
CARE Checklist (2016) statement: The authors read the CARE Checklist (2016) and prepared and revised the manuscript accordingly.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xin Li, MD, PhD, Director, Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, No. 110 Ganhe Road, Shanghai 200437, China.
Received: May 31, 2022
Peer-review started: May 31, 2022
First decision: June 27, 2022
Revised: July 9, 2022
Accepted: August 23, 2022
Article in press: August 23, 2022
Published online: October 16, 2022
Processing time: 121 Days and 3.2 Hours
Peer-review started: May 31, 2022
First decision: June 27, 2022
Revised: July 9, 2022
Accepted: August 23, 2022
Article in press: August 23, 2022
Published online: October 16, 2022
Processing time: 121 Days and 3.2 Hours
Core Tip
Core Tip: Adverse cutaneous reactions to vitamin K1 can occur; however, their diagnosis can easily be overlooked. Managing these reactions may be challenging for both patients and clinicians. Here we report a patient who developed a cutaneous allergic reaction to subcutaneous vitamin K1 that was successfully treated with herbal medicine, suggesting that Chinese medicine therapy may be a feasible way to treat adverse cutaneous reactions. We confirmed our clinical findings through physical examination, a skin biopsy, and immunohistochemical staining. We also conducted a literature review of eczematous-type reactions to clarify the possible pathogenesis and provoke new thinking regarding the clinical treatment of this disease.