Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 26, 2022; 10(27): 9851-9858
Published online Sep 26, 2022. doi: 10.12998/wjcc.v10.i27.9851
Pulmonary hypertension secondary to seronegative rheumatoid arthritis overlapping antisynthetase syndrome: A case report
Cheng-Yan Huang, Ming-Jie Lu, Jia-Hua Tian, Dai-Shun Liu, Chun-Yan Wu
Cheng-Yan Huang, Ming-Jie Lu, Jia-Hua Tian, Chun-Yan Wu, Department of Respiratory Medicine, The Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi 563000, Guizhou Province, China
Dai-Shun Liu, Clinical School, Zunyi Medical University, Zunyi 563000, Guizhou Province, China
Author contributions: Huang CY was responsible for obtaining the patient’s informed consent, collecting patient data, and writing the manuscript; Lu MJ and Tian JH reviewed the literature and contributed to manuscript drafting; Wu CY and Liu DS revised the manuscript; all authors issued final approval for the version to be submitted.
Supported by the Natural Science Foundation of China, No. 82060010.
Informed consent statement: Informed written consent was obtained from the patients for the publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Dai-Shun Liu, MD, Chief Physician, Postdoc, Clinical School, Zunyi Medical University, No. 6 Xuefu West Road, Xinpu New District, Zunyi 563000, Guizhou Province, China.
Received: May 2, 2022
Peer-review started: May 2, 2022
First decision: May 30, 2022
Revised: June 11, 2022
Accepted: August 15, 2022
Article in press: August 15, 2022
Published online: September 26, 2022
Core Tip

Core Tip: The joint manifestations of antisynthetase syndrome are usually difficult to distinguish from rheumatoid arthritis (RA), particularly seronegative RA (SNRA); consequently, rheumatologists and respiratory pathologists should be aware of this rare and underrecognized special clinical phenotype. Whether this phenotype is more prone to pulmonary hypertension than a single connective tissue disease remains unknown. However, further research into anti-Jo1 antibodies, anti-RO-52, and other extractable nuclear antigen autoantibodies is necessary to facilitate the early diagnosis, evaluation, and prognosis of this overlapping clinical syndrome.