Zavrtanik H, Luzar B, Tomažič A. Intra-ampullary papillary-tubular neoplasm combined with ampullary neuroendocrine carcinoma: A case report. World J Clin Cases 2022; 10(22): 8045-8053 [PMID: 36158500 DOI: 10.12998/wjcc.v10.i22.8045]
Corresponding Author of This Article
Aleš Tomažič, PhD, Professor, Department of Abdominal Surgery, University Medical Centre Ljubljana, Zaloška cesta 7, Ljubljana 1000, Slovenia. ales.tomazic@kclj.si
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Aug 6, 2022; 10(22): 8045-8053 Published online Aug 6, 2022. doi: 10.12998/wjcc.v10.i22.8045
Intra-ampullary papillary-tubular neoplasm combined with ampullary neuroendocrine carcinoma: A case report
Hana Zavrtanik, Boštjan Luzar, Aleš Tomažič
Hana Zavrtanik, Aleš Tomažič, Department of Abdominal Surgery, University Medical Centre Ljubljana, Ljubljana 1000, Slovenia
Boštjan Luzar, Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana 1000, Slovenia
Aleš Tomažič, Faculty of Medicine, University of Ljubljana, Ljubljana 1000, Slovenia
Author contributions: Zavrtanik H reviewed the literature and contributed to manuscript drafting; Luzar B performed the pathological analysis; Luzar B and Tomažič A critically revised the manuscript for important intellectual content; all authors read and approved the final version of the manuscript.
Informed consent statement: Written informed consent was obtained from the patient for the publication of this case report.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest with regard to this case report.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Aleš Tomažič, PhD, Professor, Department of Abdominal Surgery, University Medical Centre Ljubljana, Zaloška cesta 7, Ljubljana 1000, Slovenia. ales.tomazic@kclj.si
Received: March 21, 2022 Peer-review started: March 21, 2022 First decision: April 25, 2022 Revised: May 3, 2022 Accepted: June 22, 2022 Article in press: June 22, 2022 Published online: August 6, 2022 Processing time: 122 Days and 12.9 Hours
Core Tip
Core Tip: The ampulla of Vater is a transitional region with various distinctive histomorphologic characteristics, although the simultaneous occurrence of neuroendocrine and non-neuroendocrine tumors in this region is rare. When present, problems arise in differentiation between mixed neuroendocrine–non-neuroendocrine neoplasm and the collision of two distinct tumors. Due to the rarity of such tumors, their clinical behavior remains largely unknown, as do appropriate treatment measures. After radical resection, if feasible, the standard of care for the most aggressive and/or predominant component of the tumor from the same site of origin may be adopted. Newly diagnosed cases should be discussed at multidisciplinary team meetings to tailor postoperative treatment and follow-up appropriately.
