Meta-Analysis
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 6, 2022; 10(22): 7872-7882
Published online Aug 6, 2022. doi: 10.12998/wjcc.v10.i22.7872
Effect of celecoxib on improving depression: A systematic review and meta-analysis
Zhi Wang, Qiao Wu, Qing Wang
Zhi Wang, Integrated Traditional Chinese Medicine & Western Medicine Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Qiao Wu, Department of Neurology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Qing Wang, Department of Rehabilitation Center of Wuhan Puren Hospital, Wuhan University of Science and Technology, Wuhan 430080, Hubei Province, China
Author contributions: Wu Q and Wang Z contributed to database search, data extraction and data analysis; Wang Q contributed to paper writing and revision; All authors confirmed the final version of the manuscript.
Supported by the Sixth Batch of Wuhan Young and Middle-aged Medical Backbone Talents Training Project Wuhan Health and Family Planning Commission, No. [2018] 116.
Conflict-of-interest statement: We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in, or the review of, the manuscript entitled.
PRISMA 2009 Checklist statement: We have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qing Wang, PhD, Associate Professor, Department of Rehabilitation Center of Wuhan Puren Hospital, Wuhan University of Science and Technology, No. 1 Benxi Street, Qingshan District, Wuhan 430080, Hubei Province, China. qingpin6686@126.com
Received: February 27, 2022
Peer-review started: February 27, 2022
First decision: April 13, 2022
Revised: April 14, 2022
Accepted: June 24, 2022
Article in press: June 24, 2022
Published online: August 6, 2022
Processing time: 144 Days and 17 Hours
Core Tip

Core Tip: There is inconsistency about the efficacy of celecoxib in improving depression. This is an updated systematic review and meta-analysis that includes more than 10 additional clinical trials compared to the previous meta-analysis. We compared the depression scale scores between the celecoxib group and the control group, and celecoxib had a significant reduction in depression scale scores and could be effective in improving depression.