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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 6, 2022; 10(22): 7760-7771
Published online Aug 6, 2022. doi: 10.12998/wjcc.v10.i22.7760
Published online Aug 6, 2022. doi: 10.12998/wjcc.v10.i22.7760
Application of metagenomic next-generation sequencing in the diagnosis of infectious diseases of the central nervous system after empirical treatment
Ying-Ying Chen, Yan Guo, Xin-Hong Xue, Department of Neurology, Liaocheng People's Hospital, Liaocheng 252000, Shandong Province, China
Feng Pang, Central Laboratory, Liaocheng People's Hospital, Liaocheng 252000, Shandong Province, China
Author contributions: Guo Y and Xue XH contributed equally to this work; Guo Y collected data, analysis and drafted the initial manuscript, and reviewed and revised the manuscript; Chen YY and Xue XH performed data analysis, drafted, and revised the manuscript; Xue XH and Pang F reviewed and revised the manuscript; and All authors read and approved the final manuscript.
Institutional review board statement: The protocol has been reviewed by the Human Research Ethics Committee of the Institutional Review Board of Liaocheng people's Hospital Medical College Hospital.
Informed consent statement: The patient has signed an informed consent form.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: The original contributions presented in the study are publicly available
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying-Ying Chen, PhD, Additional Professor, Department of Neurology, Liaocheng People's Hospital, No. 67 Dongchang West Road, Liaocheng 252000, Shandong Province, China. chen323232azqiqi@163.com
Received: February 11, 2022
Peer-review started: February 11, 2022
First decision: April 13, 2022
Revised: April 27, 2022
Accepted: June 13, 2022
Article in press: June 13, 2022
Published online: August 6, 2022
Processing time: 160 Days and 22.5 Hours
Peer-review started: February 11, 2022
First decision: April 13, 2022
Revised: April 27, 2022
Accepted: June 13, 2022
Article in press: June 13, 2022
Published online: August 6, 2022
Processing time: 160 Days and 22.5 Hours
Core Tip
Core Tip: The study found that metagenomic next-generation sequencing (mNGS) had a higher sensitivity than the conventional methods in the diagnosis of infectious diseases of the central nervous system after empirical treatment. mNGS has significant clinical value and should be used mainly in early pathogen diagnosis in the future.