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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 6, 2022; 10(19): 6580-6586
Published online Jul 6, 2022. doi: 10.12998/wjcc.v10.i19.6580
Published online Jul 6, 2022. doi: 10.12998/wjcc.v10.i19.6580
Immunoadsorption therapy for Klinefelter syndrome with antiphospholipid syndrome in a patient: A case report
You Song, Cheng Wang, Rong Du, Department of Rheumatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Yong-Zhen Xiao, Health Management Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Author contributions: Song Y and Xiao YZ contributed equally to this work; Song Y had a major role in writing the manuscript and collecting the data; Xiao YZ had a major role in writing the manuscript, collecting the data and editing the images and figures; Wang C had a major role in conceptualizing and initializing the study, collecting the data and reviewed the manuscript; All authors had final approval of this manuscript.
Informed consent statement: Subjects signed an informed consent form before being included in the study.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rong Du, PhD, Associate Professor, Departments of Rheumatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, Hubei Province, China. dudurong2003@126.com
Received: December 24, 2021
Peer-review started: December 24, 2021
First decision: February 8, 2022
Revised: February 12, 2022
Accepted: May 13, 2022
Article in press: May 13, 2022
Published online: July 6, 2022
Peer-review started: December 24, 2021
First decision: February 8, 2022
Revised: February 12, 2022
Accepted: May 13, 2022
Article in press: May 13, 2022
Published online: July 6, 2022
Core Tip
Core Tip: We describe a 31-year-old male patient with chromosome 47 XXY type who suffered from deep vein thrombosis of the lower limbs accompanied by abnormal antiphospholipid antibody, lupus anticoagulant and factor VIII. After treatment with immunoadsorption therapy, glucocorticoids, cyclophosphamide, intravenous immunoglobulin and anticoagulant therapies, the patient showed dramatic symptomatic improvement. During the follow-up, the patient did not develop any new thrombotic events.