Song Y, Xiao YZ, Wang C, Du R. Immunoadsorption therapy for Klinefelter syndrome with antiphospholipid syndrome in a patient: A case report. World J Clin Cases 2022; 10(19): 6580-6586 [PMID: 35979279 DOI: 10.12998/wjcc.v10.i19.6580]
Corresponding Author of This Article
Rong Du, PhD, Associate Professor, Departments of Rheumatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, Hubei Province, China. dudurong2003@126.com
Research Domain of This Article
Rheumatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 6, 2022; 10(19): 6580-6586 Published online Jul 6, 2022. doi: 10.12998/wjcc.v10.i19.6580
Immunoadsorption therapy for Klinefelter syndrome with antiphospholipid syndrome in a patient: A case report
You Song, Yong-Zhen Xiao, Cheng Wang, Rong Du
You Song, Cheng Wang, Rong Du, Department of Rheumatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Yong-Zhen Xiao, Health Management Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Author contributions: Song Y and Xiao YZ contributed equally to this work; Song Y had a major role in writing the manuscript and collecting the data; Xiao YZ had a major role in writing the manuscript, collecting the data and editing the images and figures; Wang C had a major role in conceptualizing and initializing the study, collecting the data and reviewed the manuscript; All authors had final approval of this manuscript.
Informed consent statement: Subjects signed an informed consent form before being included in the study.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rong Du, PhD, Associate Professor, Departments of Rheumatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, Hubei Province, China. dudurong2003@126.com
Received: December 24, 2021 Peer-review started: December 24, 2021 First decision: February 8, 2022 Revised: February 12, 2022 Accepted: May 13, 2022 Article in press: May 13, 2022 Published online: July 6, 2022 Processing time: 181 Days and 19.2 Hours
Abstract
BACKGROUND
Klinefelter syndrome (KS) is a genetic disease of male sex chromosome malformations that affects sperm production and reduces testosterone production. It has been reported that there is currently more than 10 cases of KS combined with antiphospholipid syndrome.
CASE SUMMARY
Here, we describe a 31-year-old male patient with chromosome 47, XXY type, who suffered deep vein thrombosis of the lower limbs accompanied by abnormal antiphospholipid antibody, lupus anticoagulant and factor VIII. After treatment with immunoadsorption therapy, glucocorticoids, cyclophosphamide, intravenous immunoglobulin and anticoagulant therapy, the patient showed dramatic symptomatic improvement. During the follow-up, the patient did not develop any new thrombotic events.
CONCLUSION
Immunoadsorption combined with glucocorticoid and cyclophosphamide shock comprehensive treatment has achieved significant results for patients with KS combined with antiphospholipid syndrome.
Core Tip: We describe a 31-year-old male patient with chromosome 47 XXY type who suffered from deep vein thrombosis of the lower limbs accompanied by abnormal antiphospholipid antibody, lupus anticoagulant and factor VIII. After treatment with immunoadsorption therapy, glucocorticoids, cyclophosphamide, intravenous immunoglobulin and anticoagulant therapies, the patient showed dramatic symptomatic improvement. During the follow-up, the patient did not develop any new thrombotic events.
