Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 6, 2022; 10(16): 5463-5469
Published online Jun 6, 2022. doi: 10.12998/wjcc.v10.i16.5463
Diagnostic value of bone marrow cell morphology in visceral leishmaniasis-associated hemophagocytic syndrome: Two case reports
Shu-Lan Shi, Heng Zhao, Beng-Jiang Zhou, Ming-Biao Ma, Xiao-Juan Li, Ji Xu, Hong-Chao Jiang
Shu-Lan Shi, Ming-Biao Ma, Xiao-Juan Li, Ji Xu, Clinical Laboratory, The Kunming Children's Hospital, Kunming 650228, Yunnan Province, China
Heng Zhao, Department of Viro-immunology, Institute of Medical Biology Chinese Academy of Medical Sciences, Kunming 650118, Yunnan Province, China
Beng-Jiang Zhou, Department of Parasitology, Kunming Medical University Haiyuan College, Kunming 650031, Yunnan Province, China
Hong-Chao Jiang, Yunnan Key Laboratory of Children's Major Disease Research, The Kunming Children's Hospital, Kunming 650228, Yunnan Province, China
Author contributions: Shi SL, Zhao H, and Zhou BJ equally contributed to this manuscript; Shi SL and Zhao H wrote the manuscript and carried out the analysis; Ma MB, Li XJ, and Xu J investigated the cases; Zhou BJ and Jiang HC designed and supervised this study; and all authors read and approved the final manuscript.
Supported by the Association Foundation Program of Yunnan Science and Technology Department and Kunming Medical University, No. 2019FE001-103; Yunnan Health Training Project of High Level Talents, No. D-2017053; Top Young Experts Training Project for the Academy and Technology in Kunming and Yunnan Province, No. 202005AC160066; Postdoctoral Training Program of Yunnan Province, No. Ynbh19035; and Natural Science Foundation of Yunnan Province, No. 2019-1-C-25318000002240.
Informed consent statement: Written informed consent was obtained from the patients’ legal guardian for the publication of this case report.
Conflict-of-interest statement: The authors declare no competing interests for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Chao Jiang, PhD, Research Scientist, Yunnan Key Laboratory of Children's Major Disease Research, The Kunming Children's Hospital, No. 288 Qianxing Road, Kunming 650228, Yunnan Province, China. jianghongchao@etyy.cn
Received: October 21, 2021
Peer-review started: October 21, 2021
First decision: February 15, 2022
Revised: March 7, 2022
Accepted: April 20, 2022
Article in press: April 20, 2022
Published online: June 6, 2022
Processing time: 224 Days and 1.7 Hours
Core Tip

Core Tip: This study started with the morphology of bone marrow cells, finding the pathogen from the cells, and successfully diagnosed two cases of visceral leishmaniasis related-hemophagocytic lymphohistiocytosis (VL-HLH), which was then compared and analyzed with HLH. The key criterion for differential diagnosis of VL-HLH is to find the pathogen in bone marrow cells. This has great guiding significance for clinical laboratory diagnosis and clinical treatment.