Lu Y, Zhang ZQ. Neonatal hemorrhage stroke and severe coagulopathy in a late preterm infant after receiving umbilical cord milking: A case report. World J Clin Cases 2022; 10(16): 5365-5372 [PMID: 35812658 DOI: 10.12998/wjcc.v10.i16.5365]
Corresponding Author of This Article
Zhi-Qun Zhang, PhD, Director, Department of Neonatology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, No. 261 Huansha Road, Shangcheng District, Hangzhou 310003, Zhejiang Province, China. zhiqun.zhang@163.com
Research Domain of This Article
Pediatrics
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 6, 2022; 10(16): 5365-5372 Published online Jun 6, 2022. doi: 10.12998/wjcc.v10.i16.5365
Neonatal hemorrhage stroke and severe coagulopathy in a late preterm infant after receiving umbilical cord milking: A case report
Yan Lu, Zhi-Qun Zhang
Yan Lu, Zhi-Qun Zhang, Department of Neonatology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Author contributions: Lu Y collected the medical records of the patient and drafted the manuscript; Zhi-Qun Zhang reviewed the literature and was responsible for the intellectual content of the manuscript; all authors issued final approval for the version to be submitted.
Supported byZhejiang Province Medical Science and Technology Foundation of China, No. 2021PY057.
Informed consent statement: The patient's legal guardian provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Qun Zhang, PhD, Director, Department of Neonatology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, No. 261 Huansha Road, Shangcheng District, Hangzhou 310003, Zhejiang Province, China. zhiqun.zhang@163.com
Received: August 4, 2021 Peer-review started: August 4, 2021 First decision: December 10, 2021 Revised: December 23, 2021 Accepted: April 2, 2021 Article in press: April 2, 2022 Published online: June 6, 2022 Processing time: 301 Days and 20.3 Hours
Core Tip
Core Tip: We report a case of a premature infant born at 34 wk of gestation who developed neonatal hemorrhage stroke and severe coagulopathy after receiving umbilical cord milking (UCM). The baby was small for her gestational age. She developed hypoglycemia and metabolic acidosis after hospitalization. Umbilical cord bleeding, gastric bleeding, seizure and pulmonary hemorrhage were noticed in the following three days, and physical examination showed bilateral conjunctival hemorrhage. A blood test confirmed the diagnosis of disseminated intravascular coagulation. A cranial ultrasound and a computed tomography scan showed left parenchymal brain hemorrhage with extension into the ventricular and subarachnoid spaces. Our case suggests that late preterm infants who are small for gestational age who receive UCM should undergo careful clinical assessment for intracranial hemorrhage. Supportive management such as intensive care and blood transfusion may be indicated in light of seizures and coagulopathy.
