Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 6, 2022; 10(16): 5317-5323
Published online Jun 6, 2022. doi: 10.12998/wjcc.v10.i16.5317
Crouzon syndrome in a fraternal twin: A case report and review of the literature
Xiao-Jing Li, Ji-Mei Su, Xiao-Wei Ye
Xiao-Jing Li, Ji-Mei Su, Xiao-Wei Ye, Department of Stomatology, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, Zhejiang Province, China
Author contributions: Li XJ and Su JM performed the initial review and data collection, reviewed the literature and contributed to the manuscript drafting and revision; Ye XW analyzed and interpreted the imaging findings; all authors issued final approval for the version to be submitted.
Informed consent statement: Informed written consent was obtained from the patient for the publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ji-mei Su, MD, Chief Doctor, Department of Stomatology, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, No. 3333 Binsheng Road, Hangzhou 310052, Zhejiang Province, China. 6198003@zju.edu.cn
Received: December 13, 2021
Peer-review started: December 13, 2021
First decision: January 12, 2022
Revised: January 21, 2022
Accepted: April 2, 2022
Article in press: April 2, 2022
Published online: June 6, 2022
Processing time: 171 Days and 2.7 Hours
Core Tip

Core Tip: Crouzon syndrome (CS) is an autosomal dominant inherited craniofacial disorder caused by mutations in fibroblast growth factor receptor 2, but approximately 50% of cases result from de novo mutations. This syndrome has been rarely seen and evaluated in fraternal twins, only one of whom has CS. We presented a 6-year-old fraternal twin boy diagnosed with CS who had many caries and enamel hypomineralization in the oral cavity. The boy’s parents and his fraternal twin sister did not show any abnormalities indicating CS, so we hypothesize that the fraternal twin boy’s gene mutation arose from a de novo mutation.