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World J Clin Cases. Jun 6, 2022; 10(16): 5156-5164
Published online Jun 6, 2022. doi: 10.12998/wjcc.v10.i16.5156
Advances in the clinical application of oxycodone in the perioperative period
Hong-Yang Chen, Zi-Ning Wang, Wei-Yi Zhang, Tao Zhu
Hong-Yang Chen, Wei-Yi Zhang, Tao Zhu, Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Hong-Yang Chen, Wei-Yi Zhang, Tao Zhu, The Research Units of West China(2018RU012)-Chinese Academy of Medical Sciences, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Zi-Ning Wang, Department of Anesthesiology, West China School of Clinical Medicine, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Chen HY searched and sorted out the literature, and drafted the manuscript; Wang ZN took responsibility for data curation; Zhu T and Zhang WY revised the manuscript; all authors read and approved the final manuscript.
Supported by The National Key Research and Development Program, No. 2020YFC2005303.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei-Yi Zhang, MD, Associate Chief Physician, Department of Anesthesiology, West China Hospital, Sichuan University, No. 37 Guoxue Street, Chengdu 610041, Sichuan Province, China. zhangweiyi@wchscu.cn
Received: December 22, 2021
Peer-review started: December 22, 2021
First decision: January 25, 2022
Revised: January 29, 2022
Accepted: April 4, 2022
Article in press: April 4, 2022
Published online: June 6, 2022
Processing time: 161 Days and 21.4 Hours
Core Tip

Core Tip: Oxycodone is a semi-synthetic opioid extracted from a plant derivative of tiabaine and gradually applied in clinical practice. It is an opioid μ and κ receptor agonist, a class of potent opioid analgesics. It mainly acts on smooth muscle by agonizing κ receptors to relieve visceral neuralgia; on the other hand, it can act on the central nervous system by agonizing μ receptors to produce analgesic effects.