Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 16, 2022; 10(14): 4625-4631
Published online May 16, 2022. doi: 10.12998/wjcc.v10.i14.4625
Serum-negative Sjogren's syndrome with minimal lesion nephropathy as the initial presentation: A case report
Chun-Yan Li, Yi-Man Li, Mei Tian
Chun-Yan Li, Mei Tian, Department of Rheumatology, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou Province, China
Yi-Man Li, Department of Nephrology, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou Province, China
Author contributions: Li CY and Li YM wrote the manuscript; all authors have given final approval to the version to be submitted.
Informed consent statement: Informed written consent was obtained from the patient for publication of this case report in accordance with institutional guidelines.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mei Tian, PhD, Chief Doctor, Doctor, Department of Rheumatology, Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Huichuan District, Zunyi 563003, Guizhou Province, China. 348820517@qq.com
Received: October 25, 2021
Peer-review started: October 25, 2021
First decision: December 17, 2021
Revised: December 24, 2021
Accepted: March 15, 2022
Article in press: March 15, 2022
Published online: May 16, 2022
Processing time: 199 Days and 19.4 Hours
Core Tip

Core Tip: Cases of serum-negative Sjogren's syndrome, when the patient has no symptoms of exocrine gland involvement and no hyperglobulinemia, where kidney disease is the first manifestation, and when minimal lesion nephropathy is seen in renal pathology, are rare. Therefore, minor salivary gland biopsy (MSGB) should be considered if pSS is suspected in patients who do not have the typical pSS symptoms or specific autoantibodies. MSGS has a primary value in the diagnosis of these patients.