Jin ZH, Zhao XQ, Sun HB, Zhu JL, Gao W. Effect of Xuebijing injection on myocardium during cardiopulmonary bypass: A prospective, randomized, double blind trial. World J Clin Cases 2022; 10(13): 4110-4118 [PMID: 35665116 DOI: 10.12998/wjcc.v10.i13.4110]
Corresponding Author of This Article
Wei Gao, MD, Doctor, Department of Anesthesiology, The 2nd Affiliated Hospital of Harbin Medical University, No.246 Xuefu Road,Nangang District, Harbin 150001, Heilongjiang Province, China. gaowei20055@126.com
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Randomized Controlled Trial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Zhe-Hao Jin, Xiao-Qing Zhao, Hai-Bin Sun, Jing-Li Zhu, Wei Gao, Department of Anesthesiology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Author contributions: Jin ZH and Gao W designed the study; Jin ZH and Zhao XQ collected the intraoperative data; Sun HB and Zhu JL collected the postoperative data; Gao W analyzed the data and Jin ZH wrote the paper.
Institutional review board statement: The protocol for the present study was approved by the ethics committee of the Second Affiliated Hospital of Harbin Medical University before the performance of the study (HMUIRB20140012).
Clinical trial registration statement: A predefined study protocol was registered with the Chinese Clinical Trial Registry (ChiCTR-TRC-14004628).
Informed consent statement: An informed consent form was signed by each patient or their legal guardian before enrollment.
Conflict-of-interest statement: All authors have no any conflicts of interest.
Data sharing statement: No additional data are available.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei Gao, MD, Doctor, Department of Anesthesiology, The 2nd Affiliated Hospital of Harbin Medical University, No.246 Xuefu Road,Nangang District, Harbin 150001, Heilongjiang Province, China. gaowei20055@126.com
Received: September 1, 2021 Peer-review started: September 1, 2021 First decision: November 11, 2021 Revised: November 23, 2021 Accepted: March 16, 2022 Article in press: March 16, 2022 Published online: May 6, 2022 Processing time: 241 Days and 4.9 Hours
Core Tip
Core Tip: Xuebijing injection (XBJ) significantly reduced myocardial injury in patients undergoing cardiopulmonary bypass (CPB), as demonstrated by significantly lower levels of myocardial injury markers including troponin I and creatine kinase-MB, and the preserved cardiac ejection fraction in patients in the XBJ group compared with those in the control group. The benefit of XBJ against myocardial injury was accompanied by reduced serum concentrations of inflammatory markers, including tumor necrosis factor-α, interleukin (IL)-1β and IL-8 and an increase in anti-inflammatory factor IL-10. These results suggest that perioperative XBJ is associated with attenuated cardiac injury during CPB, likely via anti-inflammatory and antioxidative mechanisms.
