Liang HP, Luo XC, Zhang YL, Liu B. Del(5q) and inv(3) in myelodysplastic syndrome: A rare case report. World J Clin Cases 2022; 10(11): 3601-3608 [PMID: 35582053 DOI: 10.12998/wjcc.v10.i11.3601]
Corresponding Author of This Article
Bei Liu, MD, PhD, Professor, Department of Hematology, The First Affiliated Hospital, Lanzhou University, No. 1 Donggangxi Road, Chengguan District, Lanzhou 730000, Gansu Province, China. liubeiff@163.com
Research Domain of This Article
Hematology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Apr 16, 2022; 10(11): 3601-3608 Published online Apr 16, 2022. doi: 10.12998/wjcc.v10.i11.3601
Del(5q) and inv(3) in myelodysplastic syndrome: A rare case report
Hai-Ping Liang, Xing-Chun Luo, Ya-Li Zhang, Bei Liu
Hai-Ping Liang, Xing-Chun Luo, Ya-Li Zhang, The First Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu Province, China
Bei Liu, Department of Hematology, The First Affiliated Hospital, Lanzhou University, Lanzhou 730000, Gansu Province, China
Author contributions: Liang HP designed the study and wrote the manuscript; Luo XC collected and analyzed the data; Zhang YL prepared figures; Liu B was in charge of patient treatment and designed the paper; all authors read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bei Liu, MD, PhD, Professor, Department of Hematology, The First Affiliated Hospital, Lanzhou University, No. 1 Donggangxi Road, Chengguan District, Lanzhou 730000, Gansu Province, China. liubeiff@163.com
Received: December 6, 2021 Peer-review started: December 6, 2021 First decision: January 25, 2022 Revised: February 3, 2022 Accepted: February 27, 2022 Article in press: February 27, 2022 Published online: April 16, 2022 Processing time: 123 Days and 8.5 Hours
Core Tip
Core Tip: We report a rare case of myelodysplastic syndrome (MDS) with two chromosomal structural abnormalities, del(5q) and inv(3). The patient evolved from the initial del(5q) to inv(3) combined with del(5q). Considering the deletion of chromosome 5q, we first treated the patient with lenalidomide. When drug resistance arose, we tried azacitidine, and the patient had a short remission. Finally, the patient refused treatment with haematopoietic stem cell transplantation (HSCT), and her condition gradually deteriorated until she was discharged from the hospital. In this rare and contradictory situation, we found that MDS patients with coexisting del(5q) and inv(3) may have a poor prognosis. However, azacitidine may play a role to some extent in MDS with del(5q) and inv(3), and HSCT may be the only way to cure the disease.
