Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 16, 2022; 10(11): 3579-3586
Published online Apr 16, 2022. doi: 10.12998/wjcc.v10.i11.3579
Anti-nuclear matrix protein 2+ juvenile dermatomyositis with severe skin ulcer and infection: A case report and literature review
Ya-Ting Wang, Yu Zhang, Tao Tang, Chong Luo, Ming-Yue Liu, Li Xu, Li Wang, Xue-Mei Tang
Ya-Ting Wang, Yu Zhang, Tao Tang, Chong Luo, Ming-Yue Liu, Li Xu, Li Wang, Xue-Mei Tang, Department of Rheumatology and Immunology; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation base of Child Development and Critical Disorders; Children’s Hospital of Chongqing Medical University, Chongqing 400014, China
Ya-Ting Wang, Yu Zhang, Tao Tang, Chong Luo, Ming-Yue Liu, Li Xu, Li Wang, Xue-Mei Tang, Chongqing Key Laboratory of Child Infection and Immunity, Children’s Hospital of Chongqing Medical University, Chongqing 400014, China
Author contributions: Tang XM conceived and designed the study and revised the manuscript; Wang YT collected medical records and wrote the manuscript; Zhang Y collected medical records and participated in its design; Tang T collected medical records and provided pictures; Luo C participated in study design and coordination; Liu MY, Xu L, and Wang L collected and organized the literature; All authors read and approved the final manuscript.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xue-Mei Tang, PhD, Chief Doctor, Department of Rheumatology and Immunology; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation base of Child Development and Critical Disorders; Children’s Hospital of Chongqing Medical University, No. 136 Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China. tangxuemei2008@163.com
Received: December 7, 2021
Peer-review started: December 7, 2021
First decision: January 25, 2022
Revised: February 7, 2022
Accepted: February 27, 2022
Article in press: February 27, 2022
Published online: April 16, 2022
Processing time: 122 Days and 9.1 Hours
Core Tip

Core Tip: Juvenile dermatomyositis (JDM) is a rare systemic autoimmune disease characterized by specific skin lesions, chronic muscle inflammation, and systemic vasculitis. We report a very rare case of JDM with severe skin ulcers and infections. By reporting the disease development and treatment of this case of a patient positive for anti-nuclear matrix protein 2 (NXP2) antibody combined with skin ulcers and performing a comprehensive literature review, we summarize JDM with skin ulcers, the clinical characteristics of JDM combined with positivity for anti-NXP2 antibody, and treatment measures for severe JDM.