Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 16, 2022; 10(11): 3511-3517
Published online Apr 16, 2022. doi: 10.12998/wjcc.v10.i11.3511
Young children with multidrug-resistant epilepsy and vagus nerve stimulation responding to perampanel: A case report
Hua Yang, Dan Yu
Hua Yang, Dan Yu, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Yang H wrote the manuscript; Yang H and Yu D collected the data and participated in patient care; Yu D reviewed and edited the manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dan Yu, MD, Doctor, Professor, Department of Pediatrics, West China Second University Hospital, Sichuan University, No. 20, Section 3, South Renmin Road, Chengdu 610041, Sichuan Province, China. yudan540@163.com
Received: August 9, 2021
Peer-review started: August 9, 2021
First decision: November 6, 2021
Revised: November 23, 2021
Accepted: February 27, 2022
Article in press: February 27, 2022
Published online: April 16, 2022
Processing time: 242 Days and 5.3 Hours
Core Tip

Core tip: We report a 4-year-old boy with multidrug-resistant epilepsy who still had frequent seizures after vagus nerve stimulation (VNS) implantation, and he showed significant response to perampanel (PER) as add-on in a dose-dependent manner. Considering its favorable cognitive profile and the similar efficacy and safety profile of PER in children aged < 12 years as in older people, we proposed that the use of PER as add-on could further reduce the seizure frequency for young children with drug-resistant epilepsy and even after VNS implantation, which may be attributed to its novel antiepileptic mechanism.