Wang HW, Li XJ, Li SJ, Lu JR, He DF. Biliary stent combined with iodine-125 seed strand implantation in malignant obstructive jaundice. World J Clin Cases 2021; 9(4): 801-811 [PMID: 33585626 DOI: 10.12998/wjcc.v9.i4.801]
Corresponding Author of This Article
Dong-Feng He, PhD, Research Scientist, Surgical Oncologist, Department of Interventional, Harbin Medical University Cancer Hospital, No. 150 Haping Street, Nangang District, Harbin 150081, Heilongjiang Province, China. 13644578588@139.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Clinical Trials Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Feb 6, 2021; 9(4): 801-811 Published online Feb 6, 2021. doi: 10.12998/wjcc.v9.i4.801
Biliary stent combined with iodine-125 seed strand implantation in malignant obstructive jaundice
Hui-Wen Wang, Xiao-Jing Li, Shi-Jie Li, Jun-Rong Lu, Dong-Feng He
Hui-Wen Wang, Xiao-Jing Li, Shi-Jie Li, Jun-Rong Lu, Dong-Feng He, Department of Interventional, Harbin Medical University Cancer Hospital, Harbin 150081, Heilongjiang Province, China
Author contributions: Wang HW and Li XJ drafted the manuscript and analyzed all the data; He DF performed the surgeries and acquired data; Li SJ and Lu JR assisted in all surgeries and data collection; He DF designed and supervised the study, analyzed all the data, and revised the manuscript.
Institutional review board statement: The study was reviewed and approved by the Medical Ethics Review Committee of Harbin Medical University Cancer Hospital.
Clinical trial registration statement: This registration policy applies to prospective, randomized, controlled trials only.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no competing interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dong-Feng He, PhD, Research Scientist, Surgical Oncologist, Department of Interventional, Harbin Medical University Cancer Hospital, No. 150 Haping Street, Nangang District, Harbin 150081, Heilongjiang Province, China. 13644578588@139.com
Received: November 3, 2020 Peer-review started: November 3, 2020 First decision: November 20, 2020 Revised: November 23, 2020 Accepted: December 10, 2020 Article in press: December 10, 2020 Published online: February 6, 2021 Processing time: 83 Days and 9.7 Hours
ARTICLE HIGHLIGHTS
Research background
Biliary stent placement can relieve biliary obstruction and improve liver function and quality of life. However, restenosis after biliary stents has a poor prognosis and is a clinical challenge.
Research motivation
In order to solve the problem of biliary stent restenosis, we should seek a better method for clinical treatment.
Research objectives
To evaluate the safety and efficacy of biliary stent combined with iodine-125 seed strand implantation in malignant obstructive jaundice.
Research methods
Sixty-seven patients were randomly divided into the biliary stent with iodine-125 group (combined group) and the biliary stent group (control group). The stent patency time and total survival time were compared between the two groups.
Research results
The present study suggests that biliary stent combined with iodine-125 seed strands could improve stent patency and median survival.
Research conclusions
Biliary stent combined with 125I seed strand implantation is safe and effective for the treatment of malignant obstructive jaundice.
Research perspectives
A multicenter study with a large sample size is needed. Accurate metrological data is needed.
