Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 26, 2021; 9(33): 10143-10150
Published online Nov 26, 2021. doi: 10.12998/wjcc.v9.i33.10143
Value of GRACE and SYNTAX scores for predicting the prognosis of patients with non-ST elevation acute coronary syndrome
Xiao-Feng Wang, Ming Zhao, Fei Liu, Guo-Rong Sun
Xiao-Feng Wang, Ming Zhao, Fei Liu, Guo-Rong Sun, Department of Cardiology, Cangzhou Central Hospital, Cangzhou 061000, Hebei Province, China
Author contributions: Wang XF, Zhao M, Fei Liu F, and Sun GR contributed to the manuscript writing, revising; All authors confirmed the revised version of the manuscript.
Institutional review board statement: The study was reviewed and approved by the Cangzhou Central Hospital Institutional Review Board.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: There is no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Feng Wang, MSc, Doctor, Department of Cardiology, Cangzhou Central Hospital, No. 16 West Xinhua Road, Yunhe District, Cangzhou 061000, Hebei Province, China. dahuanhuan888@163.com
Received: July 6, 2021
Peer-review started: July 6, 2021
First decision: July 26, 2021
Revised: August 9, 2021
Accepted: August 17, 2021
Article in press: August 17, 2021
Published online: November 26, 2021
ARTICLE HIGHLIGHTS
Research background

The GRACE score and SYNTAX score are established clinical risk stratification tools for acute coronary syndromes. However, they were seldomly discussed in patients with non-ST elevation acute coronary syndrome (NSTE-ACS) receiving different types of therapies.

Research motivation

Correct diagnosis and early treatment are critical to improve clinical outcomes in patients with NSTE-ACS. Risk stratification may be helpful for the planning of treatment strategy.

Research objectives

This study tested the ability of the GRACE and SYNTAX scores to predict outcomes in patients with NSTE-ACS.

Research methods

Patients with NSTE-ACS who received agents for secondary prevention of cardiovascular diseases, who received medical therapy plus stents or who underwent coronary artery bypass graft (CABG) surgery were enrolled in the study. GRACE and SYNTAX scores were estimated, and patients in the three groups were further subdivided into GRACE and SYNTAX score tertile groups. Data on prognosis and outcomes of these patients were collected over a 46 mo follow-up period. The incidence of major adverse cardiovascular events (MACEs) was calculated. The relationship between GRACE and SYNTAX scores and prognosis and outcomes of this population were analyzed and the abilities of GRACE and SYNTAX scores to predict prognosis and outcomes especially MACE were tested.

Research results

The incidence of MACE was lower in patients having low and high GRACE and SYNTAX scores who received agents than in patients who underwent stent placement or CABG. Multivariate Cox regression analyses revealed that GRACE and SYNTAX scores were independent factors influencing the occurrence of MACE in patients with NSTE-ACS.

Research conclusions

GRACE and SYNTAX scores are useful in predicting MACE in risk stratifying patients with NSTE-ACS who undergo CABG.

Research perspectives

The findings need further studies with a larger number of participants to be confirmed.