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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Clinicopathological features of small T1 colorectal cancers
Yuki Takashina, Shin-Ei Kudo, Katsuro Ichimasa, Yuta Kouyama, Kenichi Mochizuki, Yoshika Akimoto, Yasuharu Maeda, Yuichi Mori, Masashi Misawa, Noriyuki Ogata, Toyoki Kudo, Tomokazu Hisayuki, Takemasa Hayashi, Kunihiko Wakamura, Naruhiko Sawada, Toshiyuki Baba, Fumio Ishida, Kazunori Yokoyama, Mitsuru Daita, Tetsuo Nemoto, Hideyuki Miyachi
Yuki Takashina, Shin-Ei Kudo, Katsuro Ichimasa, Yuta Kouyama, Kenichi Mochizuki, Yoshika Akimoto, Yasuharu Maeda, Yuichi Mori, Masashi Misawa, Noriyuki Ogata, Toyoki Kudo, Tomokazu Hisayuki, Takemasa Hayashi, Kunihiko Wakamura, Naruhiko Sawada, Toshiyuki Baba, Fumio Ishida, Hideyuki Miyachi, Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan
Yuki Takashina, Kazunori Yokoyama, Mitsuru Daita, Department of Gastroenterology, Nikko Kinen Hospital, Muroran 051-8501, Japan
Yuichi Mori, Clinical Effectiveness Research Group, Institute of Health and Society, University of Oslo, Oslo 0001, Norway
Tetsuo Nemoto, Department of Pathology, Showa University Nothern Yokohama Hospital, Yokohama 224-8503, Japan
Author contributions: Takashina Y, Kudo SE, Ichimasa K and Miyachi H did the study concept and design; Takashina Y, Ichimasa K, Kouyama Y, Mochizuki K, Akimoto Y, Maeda Y, Mori Y Misawa M, Ogata N, Kudo T, Hisayuki T, Hayashi T, Wakamura K, Sawada N, Baba T, Ishida F, Yokoyama K, Daita M, Nemoto T and Miyachi H Collected the data; Takashina Y, Mochizuki K, Maeda Y, Mori Y, Misawa M, Ogata N, Kudo T, Hisayuki T, Hayashi T, Wakamura K, Baba T, Ishida F and Miyachi H revised the article critically; Kudo SE and Miyachi H supervised the study.
Institutional review board statement: This study was approved by the institutional review board of Showa University Northern Yokohama Hospital, No. 19H057; and the University Hospital Medical Network Clinical Trials Registry No. UMIN000043922.
Informed consent statement: Written informed consent was obtained from all patients before treatment.
Conflict-of-interest statement: All authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
http://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Katsuro Ichimasa, MD, PhD, Assistant Professor, Digestive Disease Center, Showa University Northern Yokohama Hospital, Tsuzuki-ku, chigasakichuou, 35-1, Yokohama 224-8503, Japan. ichitommy14@yahoo.co.jp
Received: April 27, 2021
Peer-review started: April 27, 2021
First decision: June 13, 2021
Revised: June 14, 2021
Accepted: October 11, 2021
Article in press: October 11, 2021
Published online: November 26, 2021
ARTICLE HIGHLIGHTS
Research background
Additional surgical resection of T1 colorectal cancer after endoscopic resection is determined according to the risk of lymph node metastasis (LNM) on the basis of the histopathological findings of resected specimens.
Research motivation
Clinicopathological features including the rate of LNM in small (< 10 mm) T1 colorectal cancer were unknown.
Research objectives
The purpose of this study was to clarify the clinicopathological characteristics of small (< 10 mm) T1 colorectal cancer compared with large (≥ 10 mm) tumors.
Research methods
We retrospectively analyzed clinicopathological features, including the rate of LNM, of 1152 T1 colorectal cancers divided into two groups: small (< 10 mm) and large (≥ 10 mm) tumors.
Research results
Small T1 colorectal cancer had a similar rate of LNM, followed by a positive rate of histological grade and lymphovascular invasion, compared with large tumors.
Research conclusions
Because there were no significant differences in the rate of LNM between small and large T1 colorectal cancers, the decision on whether to undertake secondary surgical resection should be determined according to pathological findings, regardless of tumor size.
Research perspectives
Because this was a single-center retrospective study, prospective multicenter studies are required to validate these findings.
