Koutsoumpas A, Perera R, Melton A, Kuker J, Ghosh T, Braden B. Tunneled biopsy is an underutilised, simple, safe and efficient method for tissue acquisition from subepithelial tumours. World J Clin Cases 2021; 9(21): 5822-5829 [PMID: 34368301 DOI: 10.12998/wjcc.v9.i21.5822]
Corresponding Author of This Article
Barbara Braden, FEBG, FRCP, Professor, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, Headley Way, Oxford OX3 9DU, United Kingdom. braden@em.uni-frankfurt.de
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Cohort Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 26, 2021; 9(21): 5822-5829 Published online Jul 26, 2021. doi: 10.12998/wjcc.v9.i21.5822
Tunneled biopsy is an underutilised, simple, safe and efficient method for tissue acquisition from subepithelial tumours
Andreas Koutsoumpas, Ruwan Perera, Adele Melton, Jonathan Kuker, Tilak Ghosh, Barbara Braden
Andreas Koutsoumpas, Ruwan Perera, Adele Melton, Barbara Braden, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DU, United Kingdom
Jonathan Kuker, Senior School, Magdalen College School, Oxford OX4 0DZ, United Kingdom
Tilak Ghosh, Translational Gastroenterology Unit, Oxford University Hospital NHS Foundation Trust, Oxford OX3 9DU, United Kingdom
Author contributions: All authors contributed in data acquisition, analysis and interpretation of the data, critically revised, edited and approved the final version; Braden B drafted the study concept and first manuscript version; Koutsoumpas A and Perera R contributed equally and are shared first authors.
Institutional review board statement: The observational retrospective nature of the study was established with the Health Research Authority and Trust RD department. According to the Health Research Authority, this type of study does not require approval from a research ethics committee.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available to share.
STROBE statement: The authors have read the STROBE statement-checklist of items, and the manuscript was prepared and revised accordingly.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Barbara Braden, FEBG, FRCP, Professor, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, Headley Way, Oxford OX3 9DU, United Kingdom. braden@em.uni-frankfurt.de
Received: March 21, 2021 Peer-review started: March 21, 2021 First decision: April 29, 2021 Revised: May 10, 2021 Accepted: May 26, 2021 Article in press: May 26, 2021 Published online: July 26, 2021
ARTICLE HIGHLIGHTS
Research background
Subepithelial tumours of the gastrointestinal tract can be benign, pre-malignant or malignant. Most small tumours are benign. Lipoma, leiomyoma, pancreatic rests or duplications cyst will usually not need further follow-up. Gastrointestinal stromal tumours or neuroendocrine tumours will require resection or surveillance. Metastasis to the gastrointestinal wall can rarely also present as subepithelial lesion.
Research motivation
Histology acquisition from subepithelial tumours is challenging as conventional endoscopic biopsies do usually not reach deeper than the mucosal layer. Subepithelial tumours often present a diagnostic dilemma.
Research objectives
The authors investigated the use, the safety and the diagnostic success of performing tunnel biopsies from subepithelial tumours to obtain histology.
Research methods
Tunnel biopsy was defined as repeating at least 10 double pass biopsies targeting the identical spot on the subepithelial mass with conventional biopsy forceps. All patients with subepithelial tumours reported at oesophagogastroduodenoscopy presenting within the 6 year study period were included and data were analysed regarding size and location of the tumour, histology, radiological findings, re-admissions and adverse events.
Research results
Only in about half of the 229 encountered subepithelial tumours tunnel biopsies were attempted. However, when tunnel biopsies were performed, they were diagnostic in 53.6%. Adverse events were not observed.
Research conclusions
Performing tunnel biopsies from subepithelial tumours during endoscopy prolongs the procedure only a few minutes but can save endoscopic ultrasound-guided sampling or the need for follow-up in about 50%.
Research perspectives
Further randomized studies with cost-analysis should assess the diagnostic yield of tunnel biopsies performed at the index endoscopy compared with endoscopic ultrasound-guided sampling.
