Xiong JX, Cai T, Hu L, Chen XL, Huang K, Chen AJ, Wang P. Risk factors related to postoperative recurrence of dermatofibrosarcoma protuberans: A retrospective study and literature review. World J Clin Cases 2021; 9(20): 5442-5452 [PMID: 34307598 DOI: 10.12998/wjcc.v9.i20.5442]
Corresponding Author of This Article
Ping Wang, PhD, Doctor, Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing 400010, China. wang_ping@zju.edu.cn
Research Domain of This Article
Dermatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 16, 2021; 9(20): 5442-5452 Published online Jul 16, 2021. doi: 10.12998/wjcc.v9.i20.5442
Risk factors related to postoperative recurrence of dermatofibrosarcoma protuberans: A retrospective study and literature review
Jian-Xia Xiong, Tao Cai, Li Hu, Xiao-Li Chen, Kun Huang, Ai-Jun Chen, Ping Wang
Jian-Xia Xiong, Tao Cai, Li Hu, Xiao-Li Chen, Kun Huang, Ai-Jun Chen, Ping Wang, Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
Author contributions: Xiong JX and Wang P contributed equally to this work; Xiong JX, Cai T, Hu L, and Wang P designed the research study; Xiong JX acquired the clinical data; Wang P and Chen XL performed the research; Chen AJ consulted the literature relevant to DFSP; Huang K contributed analytic tools; Xiong JX and Wang P analyzed the data and wrote the manuscript; Cai T revised the manuscript; all authors have read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the First Affiliated Hospital of Chongqing Medical University Institutional Review Board (No. 2020-653).
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors declare that there is no conflict of interests regarding the publication of this paper.
Data sharing statement: Statistical code, and data set available from the corresponding author at (email: wang_ping@zju.edu.cn). Participants gave informed consent for data sharing but the presented data are anonymized and risk of identification is low.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ping Wang, PhD, Doctor, Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing 400010, China. wang_ping@zju.edu.cn
Received: January 19, 2021 Peer-review started: January 19, 2021 First decision: April 15, 2021 Revised: April 20, 2021 Accepted: May 19, 2021 Article in press: May 19, 2021 Published online: July 16, 2021
ARTICLE HIGHLIGHTS
Research background
Dermatofibrosarcoma protuberans (DFSP) is a rare skin and soft tissue malignant tumor with low grade, accounting for 1% of all soft tissue malignant tumors. The tumor has a high recurrence rate after operation.
Research motivation
To evaluate the clinical manifestations, pathological features, and immune molecules of DFSP, and identify risk factors that may be related to prognosis.
Research objectives
To clarity whether there are some clinical or pathological features related to prognosis of DFSP.
Research methods
This study is a retrospective analysis. We analyzed the tumor size, treatment experience, operation scope, and other dimensions, and quantified the relevant information. SPSS21.0 statistical software was adopted for statistical analyses.
Research results
A total of 44 patients with DFSP were included and 42 cases were followed, of whom four experienced relapse, with a recurrence rate of 9.52%. For patients with a previous history of recurrence, the recurrence risk was higher than that in the patients with primary tumor (19.05% vs 0% P = 0.028). The recurrence risk in those patients with misdiagnosis experience was higher than that in the patients without (68% vs 36.84%, P = 0.04). The tumor diameter in patients with treatment history was larger than that in patients treated for the first time (4.75 ± 0.70 cm vs 2.25 ± 0.36 cm, P = 0.004).
Research conclusions
Tumor location and previous treatment history have an impact on the prognosis of the disease. However, the above factors indirectly affect the prognosis by affecting the extent of surgical resection. Repeated and incomplete treatment can lead to the enlargement of the tumor, which in turn affects the scope of surgical resection. In addition, no immune markers related to postoperative recurrence was found.
Research perspectives
In the future, we will continue to follow all patients to analyze the causes of death and the risk factors that may lead to death. And we will devote ourselves to finding immune markers related to the prognosis of patients with DFSP.
