Wang YK, Shen L, Yun T, Yang BF, Zhu CY, Wang SN. Histopathological classification and follow-up analysis of chronic atrophic gastritis. World J Clin Cases 2021; 9(16): 3838-3847 [PMID: 34141740 DOI: 10.12998/wjcc.v9.i16.3838]
Corresponding Author of This Article
Su-Nan Wang, PhD, Research Assistant Professor, Shenzhen Vocational and Technical College, Bank of Xili Lake, Xilihu Town, Nanshan District, Shenzhen 518055, Guangdong Province, China. wangsunan@szpt.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 6, 2021; 9(16): 3838-3847 Published online Jun 6, 2021. doi: 10.12998/wjcc.v9.i16.3838
Histopathological classification and follow-up analysis of chronic atrophic gastritis
Yang-Kun Wang, Lan Shen, Tian Yun, Bin-Feng Yang, Chao-Ya Zhu, Su-Nan Wang
Yang-Kun Wang, Department of Pathology, Shenzhen Hospital of Southern Medical University, Shenzhen 518100, Guangdong Province, China
Lan Shen, Department of Pathology, Shenzhen Hospital of Southern Medical University, Shenzhen 518055, Guangdong Province, China
Tian Yun, Department of Pathology, 989th Hospital of PLA, Luoyang 471000, Henan Province, China
Bin-Feng Yang, Department of Pathology, Xinxiang Central Hospital, Xinxiang 453000, Henan Province, China
Chao-Ya Zhu, Department of Pathology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Su-Nan Wang, Shenzhen Vocational and Technical College, Shenzhen 518055, Guangdong Province, China
Author contributions: Wang YK and Wang SN participated in the design of this study, and they both performed the statistical analysis; Shen L, Yun T, Yang BF, and Zhu CY carried out the study and collected important background information; Wang YK, Shen L, and Yun T drafted the manuscript; all authors read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by Luoyang Medical Research Institutional Review Board.
Informed consent statement: All subjects gave written informed consent prior to study inclusion.
Conflict-of-interest statement: The authors have no conflicts of interest to disclose.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Su-Nan Wang, PhD, Research Assistant Professor, Shenzhen Vocational and Technical College, Bank of Xili Lake, Xilihu Town, Nanshan District, Shenzhen 518055, Guangdong Province, China. wangsunan@szpt.edu.cn
Received: August 5, 2020 Peer-review started: August 5, 2020 First decision: October 18, 2020 Revised: November 12, 2020 Accepted: March 18, 2021 Article in press: March 18, 2021 Published online: June 6, 2021 Processing time: 282 Days and 7 Hours
ARTICLE HIGHLIGHTS
Research background
Chronic atrophic gastritis (CAG) is a common lesion in gastric mucosal biopsy tissue. The classification of CAG into the mild, moderate, and severe cannot reflect the histomorphology characteristics. Moreover, this classification only describes gland atrophy and mucosal thinning, ignoring the relationship between malignant transformation of cells, histomorphology findings, and early gastric cancer.
Research motivation
The old classification system is not appropriate in actual work, and there are often some exceptions.
Research objectives
To develop a new classification system in practical work.
Research methods
To observe the role of the new classification in clinical application from the clinical manifestations, histopathological morphology, and follow-up review.
Research results
Each of the four classifications has its own characteristics. The definition and pictures are given in the article, which is more practical than the previous classification system.
Research conclusions
This study divides CAG into four types: Simple, hyperplastic, intestinal metaplasia, and intraepithelial neoplasia types. This classification is based on the morphological characteristics of gastric mucosal atrophy in the clinical pathology report. Moreover, the recommended follow-up time is proposed.
Research perspectives
Future research should be undertaken to assess the clinical effects of applying this classification to more samples. The new classification has an appreciated effect in preventing atrophic gastritis from developing into gastric cancer.
