Li TG, Nie F, Xu XY. Correlation between ductus venosus spectrum and right ventricular diastolic function in isolated single-umbilical-artery foetus and normal foetus in third trimester. World J Clin Cases 2020; 8(23): 5866-5875 [PMID: 33344585 DOI: 10.12998/wjcc.v8.i23.5866]
Corresponding Author of This Article
Fang Nie, MD, Chief Doctor, Chief Physician, Professor, Department of Ultrasound Diagnosis, Lanzhou University Second Hospital, No. 82 Cuiyingmen, Chengguan District, Lanzhou 733000, Gansu Province, China. fang_nie_1969@126.com
Research Domain of This Article
Obstetrics & Gynecology
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Dec 6, 2020; 8(23): 5866-5875 Published online Dec 6, 2020. doi: 10.12998/wjcc.v8.i23.5866
Correlation between ductus venosus spectrum and right ventricular diastolic function in isolated single-umbilical-artery foetus and normal foetus in third trimester
Tian-Gang Li, Fang Nie, Xiao-Yan Xu
Tian-Gang Li, Xiao-Yan Xu, Department of Ultrasound Diagnosis, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou 730050, Gansu Province, China
Fang Nie, Department of Ultrasound Diagnosis, Lanzhou University Second Hospital, Lanzhou 733000, Gansu Province, China
Author contributions: Li TG carried out imaging, participated in image acquisition and analysis, participated in the design of the study and drafted the manuscript; Nie F participated in the design and coordination of the study; Xu XY conceived of the study, participated in its design and coordination and performed the statistical analysis; All authors read and approved the final manuscript.
Institutional review board statement: The study protocol was approved by the Medical Ethics Committee of Gansu Provincial Maternity and Child-Care Hospital.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: The data and material in the current study are available from the corresponding author upon reasonable request.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fang Nie, MD, Chief Doctor, Chief Physician, Professor, Department of Ultrasound Diagnosis, Lanzhou University Second Hospital, No. 82 Cuiyingmen, Chengguan District, Lanzhou 733000, Gansu Province, China. fang_nie_1969@126.com
Received: April 18, 2020 Peer-review started: April 18, 2020 First decision: September 14, 2020 Revised: September 23, 2020 Accepted: October 26, 2020 Article in press: October 26, 2020 Published online: December 6, 2020 Processing time: 229 Days and 20.7 Hours
ARTICLE HIGHLIGHTS
Research background
Single umbilical artery (SUA) is the most common umbilical cord malformation in prenatal diagnosis. The presence of an SUA can cause blood circulation disorder in the foetus and functional changes of the foetal heart, affecting foetal circulation.
Research motivation
We used ductus venosus (DV) velocity for the evaluation of right ventricular diastolic function in foetuses with isolated SUA and in those with normal cardiac anatomy.
Research objectives
The right ventricular diastolic functions in foetuses with isolated SUA and normal foetuses in the third trimester were evaluated using the spectral Doppler of blood flow in the foetal DV.
Research methods
Colour Doppler was used to measure the spectrum of foetal DV and tricuspid orifice in SUA foetuses and in age-matched healthy controls. The DV flow velocities and velocity ratios were measured. The early passive/late active ratio at the tricuspid orifice and tissue Doppler Tei index of the foetal right ventricular in the two groups were measured.
Research results
During the third trimester, the isolated SUA group showed a lower ‘a’-wave peak velocity in the DV than the control group. The correlation between the ventricular late diastolic velocity/ventricular diastolic peak flow velocity and early passive/late active ratios was the best. The correlation between the pulsatility index for veins and tissue Doppler Tei index ratios was the best.
Research conclusions
The spectral Doppler of blood flow in the foetal DV can be used to identify the right ventricular diastolic functions of isolated SUA and healthy foetuses.
Research perspectives
Through the detection of spectral Doppler of blood flow in the foetal DV between the isolated SUA group and the control group, we can accurately evaluate the foetal ventricular diastolic function of isolated SUA to provide more accurate and objective diagnosis and treatment basis for the clinic.
