Clinical Trials Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 6, 2020; 8(15): 3249-3258
Published online Aug 6, 2020. doi: 10.12998/wjcc.v8.i15.3249
Comparison of measurements of anterior chamber angle via anterior segment optical coherence tomography and ultrasound biomicroscopy
Zi-Yan Yu, Ting Huang, Lu Lu, Bo Qu
Zi-Yan Yu, Lu Lu, Bo Qu, Department of Ophthalmology, Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, Key Laboratory of Lens Research of Liaoning Province, Shenyang 110005, Liaoning Province, China
Ting Huang, Department of Cataract, Aier Mega Ophthalmic Hospital of Chongqing, Chongqing 400060, China
Author contributions: Yu ZY and Huang T contributed equally to this work; all authors helped to perform the research; Qu B drafted the manuscript; Yu ZY, Huang T, and Lu L reviewed the published articles and analyzed the data; all authors read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Fourth Affiliated Hospital of China Medical University.
Clinical trial registration statement: The name of the trail registry is agreement between anterior segment optical coherence tomography, lenstar and ultrasound biomicroscopy measurements of anterior segment parameters. The registry’s URL is www.medresman.org and the registration number is ChiCTR1900021378.
Informed consent statement: Written informed consent was obtained from all the patients.
Conflict-of-interest statement: The authors have stated that they have no conflicts of interest.
Data sharing statement: The datasets of this study are readily available from the corresponding author on reasonable request.
CONSORT 2010 statement: The guidelines of the CONSORT 2010 statement have been adopted.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Bo Qu, MD, PhD, Associate Professor, Department of Ophthalmology, Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, Key Laboratory of Lens Research of Liaoning Province, No. 11 Xinhua Road, Shenyang 110005, Liaoning Province, China. dolphinemu@foxmail.com
Received: April 9, 2020
Peer-review started: April 9, 2020
First decision: April 29, 2020
Revised: May 11, 2020
Accepted: July 14, 2020
Article in press: July 14, 2020
Published online: August 6, 2020
Processing time: 119 Days and 0.1 Hours
ARTICLE HIGHLIGHTS
Research background

Glaucoma is an irreversible optic neuropathy with the loss of visual field and decrease of vision. A quick, user-friendly, and non-invasive method of assessing the anterior segment parameters is essential for early screening and diagnosis of glaucoma.

Research motivation

The main topic is to compare the difference between anterior chamber angle parameters measured by different methods.

Research objectives

To investigate the agreement, difference, and correlation of chamber angle parameters such as angel opening distance at 500 μm (AOD500) and trabeculo-iris space area at 500 μm2 (TISA500) measured by anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM) in normal subjects.

Research methods

Both AS-OCT and UBM were performed to measure AOD500 and TISA500 in 45 subjects (72 eyes). All subjects without glaucoma were collected from October 2015 to August 2016 at the Ophthalmology Department of the Fourth Affiliated Hospital of China Medical University. Data of the two groups (AOD500 and TISA500) were compared by nonparametric tests. Pearson correlative analysis and Bland–Altman analysis were used to compare the correlation and agreement.

Research results

There were no significant differences between AS-OCT and UBM in measuring AOD500 and TISA500 of the four quadrants of the anterior chamber angle. There was a high correlation in measuring AOD500 and TISA500. There was a good agreement in measuring AOD500 and TISA500.

Research conclusions

There is a high correlation and agreement between AOD500 and TISA500 measurements by AS-OCT and UBM. They are interchangeable under some circumstances. AS-OCT proves to be a better early screening tool for glaucoma.

Research perspectives

AS-OCT and UBM are interchangable for AOD500 and TISA500 measurements and cannot be completely replaced by each other. AS-OCT can be used as the first choice for early glaucoma screening, especially for primary open-angle glaucoma patients.