Case Report
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 26, 2018; 6(14): 800-806
Published online Nov 26, 2018. doi: 10.12998/wjcc.v6.i14.800
Carney complex: Two case reports and review of literature
Shuang Li, Lian Duan, Feng-Dan Wang, Lin Lu, Zheng-Yu Jin
Shuang Li, Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
Shuang Li, Feng-Dan Wang, Zheng-Yu Jin, Department of Radiology, Peking Union Medical College Hospital, Beijing 100730, China
Lian Duan, Lin Lu, Department of Endocrinology, Peking Union Medical College Hospital, Beijing 100730, China
Author contributions: Duan L and Lu L designed the report; Wang FD and Jin ZY collected the patients’ clinical data; Li S wrote the paper.
Informed consent statement: Consent was obtained from the patients for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The guidelines of the CARE Checklist (2016) have been adopted.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Feng-Dan Wang, MD, PhD, Doctor, Department of Radiology, Peking Union Medical College Hospital, No. 1, Shuaifuyuan, Beijing 100730, China. wangfengdan@pumch.cn
Telephone: +86-10-69159608
Received: August 7, 2018
Peer-review started: August 7, 2018
First decision: October 3, 2018
Revised: October 16, 2018
Accepted: October 23, 2018
Article in press: October 23, 2018
Published online: November 26, 2018
Processing time: 111 Days and 18.1 Hours
ARTICLE HIGHLIGHTS
Case characteristics

Carney complex (CNC) is a very rare disease with diverse clinical characteristics. Osteochondromyxoma is an extremely rare kind of bone tumor, presenting within the context of 1% of CNC cases, and is specific for the diagnosis.

Clinical diagnosis

CNC.

Differential diagnosis

Peutz-Jeghers syndrome and McCune-Albright syndrome.

Laboratory diagnosis

Hypercortisolism.

Imaging diagnosis

Osteochondromyxoma.

Pathological diagnosis

Primary pigmented nodular adrenocortical disease.

Treatment

Surgery.

Related reports

Nine cases were CNC combined with osteochondromyxoma, three of which were in Japanese, Russian and Italian, and only 6 cases are reported in English literature.

Term explanation

CNC.

Experiences and lessons

This case will contribute to improvements in our understanding of the clinical and imaging features, especially osteochondromyxoma, of CNC. In clinical practice, osteochondromyxoma should be taken into account in patients with CNC complicated with skeletal lesions. Early diagnosis will help to improve the prognosis of patients.