Published online Nov 6, 2018. doi: 10.12998/wjcc.v6.i13.683
Peer-review started: May 14, 2018
First decision: June 8, 2018
Revised: July 26, 2018
Accepted: October 8, 2018
Article in press: October 9, 2018
Published online: November 6, 2018
Processing time: 176 Days and 23 Hours
This patient was referred to our department due to left flank pain for 1 wk, with no additional symptoms.
A 4 cm × 3 cm mass was found in the left adrenal region.
The findings of biochemical and hormone measurements were within the normal range.
Abdominal computed tomography (CT) of this patient revealed a 4 cm × 3 cm mass in the left adrenal region, and CT enhancement scan showed a mass in the left adrenal with no enhanced uniform.
Through the analysis of morphological pattern and immunohistochemical markers (the tumor cells were positive for CD20, CD79α, Pax5, CD2, CD3, CD5, CD21, CD23 and CD68), a diagnosis of CD was made.
The patient was treated by laparotomy.
CD was first reported by Castleman in 1954, in a patient with a large mediastinal mass. Adrenal CD is very rare. Interleukin-6 may play an important part in the pathogenesis of CD and anti-interleukin-6 receptor antibody could be a therapeutic strategy for CD.
CD is a rare disorder, for which is hard to achieve early diagnosis due to its nonspecific manifestation and radiological characteristics. Adrenal CD is extraordinarily rare and should be considered in the process of evaluating adrenal mass.