Chen J, Yang C, Liang CZ. Detection of a unicentric type of Castleman-like mass at the site of adrenal grand: A case report and review of literature. World J Clin Cases 2018; 6(13): 683-687 [PMID: 30430126 DOI: 10.12998/wjcc.v6.i13.683]
Corresponding Author of This Article
Chao-Zhao Liang, MD, PhD, Professor, Department of Urology, The First Affiliated Hospital of Anhui Medical University, Jixi Road No. 218, Hefei 230022, Anhui Province, China. liang_chaozhao@ahmu.edu.cn
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Nov 6, 2018; 6(13): 683-687 Published online Nov 6, 2018. doi: 10.12998/wjcc.v6.i13.683
Detection of a unicentric type of Castleman-like mass at the site of adrenal grand: A case report and review of literature
Jing Chen, Cheng Yang, Chao-Zhao Liang
Jing Chen, Cheng Yang, Chao-Zhao Liang, Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Author contributions: Chen J and Yang C Contributed equally to this manuscript. Chen J drafted this manuscript; Yang C analyzed and interpreted the patient data; Liang CZ evaluated the histopathological and prepared the figures; All authors read and approved the final manuscript.
Supported by the Junior Research Project Funding of Anhui Natural Science Foundation, No. 1708085QH203; National Natural Science Founding of China, No. 81700662.
Informed consent statement: Ethical approval was obtained from the Institutional Review Boards of The First Affiliated Hospital of Anhui Medical University. Informed consent was signed by the patient for the publication of this report and related images.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Chao-Zhao Liang, MD, PhD, Professor, Department of Urology, The First Affiliated Hospital of Anhui Medical University, Jixi Road No. 218, Hefei 230022, Anhui Province, China. liang_chaozhao@ahmu.edu.cn
Telephone: +86-551-63633742
Received: May 14, 2018 Peer-review started: May 14, 2018 First decision: June 8, 2018 Revised: July 26, 2018 Accepted: October 8, 2018 Article in press: October 9, 2018 Published online: November 6, 2018 Processing time: 176 Days and 23 Hours
ARTICLE HIGHLIGHTS
Case characteristics
This patient was referred to our department due to left flank pain for 1 wk, with no additional symptoms.
Clinical diagnosis
A 4 cm × 3 cm mass was found in the left adrenal region.
Laboratory diagnosis
The findings of biochemical and hormone measurements were within the normal range.
Imaging diagnosis
Abdominal computed tomography (CT) of this patient revealed a 4 cm × 3 cm mass in the left adrenal region, and CT enhancement scan showed a mass in the left adrenal with no enhanced uniform.
Pathological diagnosis
Through the analysis of morphological pattern and immunohistochemical markers (the tumor cells were positive for CD20, CD79α, Pax5, CD2, CD3, CD5, CD21, CD23 and CD68), a diagnosis of CD was made.
Treatment
The patient was treated by laparotomy.
Related reported
CD was first reported by Castleman in 1954, in a patient with a large mediastinal mass. Adrenal CD is very rare. Interleukin-6 may play an important part in the pathogenesis of CD and anti-interleukin-6 receptor antibody could be a therapeutic strategy for CD.
Experiences and lessons
CD is a rare disorder, for which is hard to achieve early diagnosis due to its nonspecific manifestation and radiological characteristics. Adrenal CD is extraordinarily rare and should be considered in the process of evaluating adrenal mass.
