Meng QZ, Wang Y, Li B, Xi Z, Wang M, Xiu JQ, Yang XP. Relationship between glycemic variability and cognitive function in lacune patients with type 2 diabetes. World J Clin Cases 2023; 11(5): 1019-1030 [PMID: 36874411 DOI: 10.12998/wjcc.v11.i5.1019]
Corresponding Author of This Article
Xiao-Peng Yang, Doctor, Chief Doctor, Department of Neurology, The Second Affiliated Hospital of Zhengzhou University, Jingba Road, Jinshui District, Zhengzhou 450003, Henan Province, China. yaxipe39@126.com
Research Domain of This Article
Clinical Neurology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Feb 16, 2023; 11(5): 1019-1030 Published online Feb 16, 2023. doi: 10.12998/wjcc.v11.i5.1019
Relationship between glycemic variability and cognitive function in lacune patients with type 2 diabetes
Qi-Zhe Meng, Yang Wang, Bing Li, Zhi Xi, Ming Wang, Jia-Qi Xiu, Xiao-Peng Yang
Qi-Zhe Meng, Yang Wang, Bing Li, Zhi Xi, Ming Wang, Jia-Qi Xiu, Xiao-Peng Yang, Department of Neurology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450003, Henan Province, China
Author contributions: Meng QZ proposed the overall research goal and designed the research plan and model design; Yang XP conducted feasibility analysis, review and supervision of the experiment; Wang M, Li B, and Xiu JQ collected clinical data; Meng QZ and Wang Y conducted statistical processing and analysis of the data; Meng QZ and Xi Z are responsible for writing the first draft of the paper; Yang XP is responsible for the review, revision and quality control of the paper; all authors determined the final draft of the paper.
Supported bythe Medical Technology and Science Research Project in Henan Province, China, No. SBGJ202102177.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the Second Affiliated Hospital of Zhengzhou University (2022031).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: We declare that we have no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Peng Yang, Doctor, Chief Doctor, Department of Neurology, The Second Affiliated Hospital of Zhengzhou University, Jingba Road, Jinshui District, Zhengzhou 450003, Henan Province, China. yaxipe39@126.com
Received: November 7, 2022 Peer-review started: November 7, 2022 First decision: December 20, 2022 Revised: December 26, 2022 Accepted: January 10, 2023 Article in press: January 10, 2023 Published online: February 16, 2023 Processing time: 99 Days and 5.8 Hours
ARTICLE HIGHLIGHTS
Research background
Lacunes and glucose variability (GV) are gaining growing attention.
Research motivation
The association between GV, the severity of lacunes and the cognitive impairment in lacune patients with type 2 diabetes mellitus (T2DM) is still unknown.
Research objectives
To explore the correlation between GV, lacune burden and cognitive function in patients with lacunes complicated with T2DM.
Research methods
Seventy-two h continuous blood glucose monitoring was performed. The Montreal cognitive assessment was used to assess cognitive function. The burden of lacunes was evaluated using magnetic resonance imaging findings. Multifactorial logistic regression analysis was used to study the affecting the lacune load and cognitive impairment in patients. To predict the value of patients' cognitive impairment with lacunes complicated with T2DM, a receiver operating characteristic curve and a nomogram prediction model were constructed.
Research results
Standard deviation and percentage coefficient of variation (%CV) were the risk factors for an increased infarct burden in lacune patients complicated with T2DM. Time of range (TIR) is a protective factor. In addition, an increased SD, %CV were the risk factors for cognitive impairment in patients with lacunes complicated with T2DM. TIR is a protective factor.
Research conclusions
Blood glucose variability is closely associated with the level of lacune burden and cognitive dysfunction in lacune patients combined with T2DM. %CV, TIR have a certain predictive effect in cognitive impairment in lacune patients.
Research perspectives
Prospective studies are further needed to verify the results of this paper.
