Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 6, 2023; 11(28): 6725-6732
Published online Oct 6, 2023. doi: 10.12998/wjcc.v11.i28.6725
Efficacy and anti-inflammatory analysis of glucocorticoid, antihistamine and leukotriene receptor antagonist in the treatment of allergic rhinitis
Chen Qiu, Dai Feng
Chen Qiu, Department of Pharmacy, Hongshan District Health Service Center, Wuhan 430000, Hubei Province, China
Dai Feng, Department of Ear-Nose-Throat, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 430063, Hubei Province, China
Author contributions: Qiu C and Feng D contributed equally to this work; Feng D conceived and designed the experiments; Qiu C and Feng D selected the literature, extracted data and analyzed it; Feng D and Qiu C wrote the manuscript.
Institutional review board statement: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent statement: This study is a retrospective study, therefore informed consent forms are exempted.
Conflict-of-interest statement: The authors declare no competing financial interest.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chen Qiu, MD, Doctor, Department of Pharmacy, Hongshan District Health Service Center, No. 70 Nanhu Road, Hongshan District, Wuhan 430000, Hubei Province, China. qc07200@163.com
Received: August 1, 2023
Peer-review started: August 1, 2023
First decision: August 16, 2023
Revised: August 29, 2023
Accepted: September 5, 2023
Article in press: September 5, 2023
Published online: October 6, 2023
Processing time: 55 Days and 10.2 Hours
ARTICLE HIGHLIGHTS
Research background

Glucocorticoids, antihistamines and leukotriene receptor antagonists are excellent therapeutic agents for allergic rhinitis (AR) at present, but the existing research lacks the comprehensive clinical effect comparison and analysis of the three.

Research motivation

To explore the clinical and anti-inflammatory effects of glucocorticoid, antihistamine and leukotriene receptor antagonist on AR.

Research objectives

To systematically evaluate the therapeutic effect of glucocorticoid, antihistamine and leukotriene receptor antagonist on AR, and evaluate its anti-inflammatory level to guide the follow-up clinical treatment.

Research methods

To evaluate the clinical efficacy, anti-inflammatory reaction and adverse reactions before and after treatment and between groups, and to comprehensively evaluate the efficacy of leukotriene receptor antagonists, glucocorticoids and antihistamines.

Research results

All three drugs have certain therapeutic effects, and the therapeutic effect of glucocorticoid combined with antihistamine is better than that of leukotriene receptor antagonist. Glucocorticoid combined with antihistamine has better anti-inflammatory effect and lower adverse reactions.

Research conclusions

Glucocorticoids and antihistamines are more effective in the treatment of AR, and it is better to reduce the level of serum inflammatory indicators and have lower adverse reactions.

Research perspectives

Summarize the common drugs used in the treatment of AR, and comprehensively analyze the clinical efficacy, anti-inflammatory level and adverse reactions of these drugs to serve clinical treatment.