Zhang Y, Wang L, Fang ZX, Chen J, Zheng JL, Yao M, Chen WY. Mortality in patients with COVID-19 requiring extracorporeal membrane oxygenation: A meta-analysis. World J Clin Cases 2022; 10(8): 2457-2467 [PMID: 35434060 DOI: 10.12998/wjcc.v10.i8.2457]
Corresponding Author of This Article
Wen-Yu Chen, PhD, Department of Respiration, Affiliated Hospital of Jiaxing University, No. 1882 South Zhonghuan Road, Jiaxing 314000, Zhejiang Province, China. 00135116@zjxu.edu.cn
Research Domain of This Article
Respiratory System
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Mar 16, 2022; 10(8): 2457-2467 Published online Mar 16, 2022. doi: 10.12998/wjcc.v10.i8.2457
Mortality in patients with COVID-19 requiring extracorporeal membrane oxygenation: A meta-analysis
Ye Zhang, Lei Wang, Zhi-Xian Fang, Jing Chen, Jia-Lian Zheng, Ming Yao, Wen-Yu Chen
Ye Zhang, Lei Wang, Department of General Practice, Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang Province, China
Zhi-Xian Fang, Wen-Yu Chen, Department of Respiration, Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang Province, China
Jing Chen, Jia-Lian Zheng, Department of Oncology, Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang Province, China
Ming Yao, Department of Pain Medicine, Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang Province, China
Author contributions: Zhang Y, Wang L, and Fang ZX conceptualised and designed the protocol, drafted the initial manuscript, and reviewed the manuscript; Chen J and Zheng JL defined the concepts and search items, data extraction process, as well as methodological appraisal of the studies; Yao M planned the data extraction and statistical analysis; Chen WY provided critical insights; all authors have approved and contributed to the final written manuscript.
Supported byThe Jiaxing Fight Novel Coronavirus Pneumonia Emergency Technology Attack Special Project in 2020, No. 2020GZ30001; the Key Discipline of Jiaxing Respiratory Medicine Construction Project, No. 2019-zc-04; Scientific Technology Plan Program for Healthcare in Zhejiang Province, No. 2021KY1100; and A Project Supported by Scientific Research Fund of Zhejiang Provincial Education Department, No.Y202043573 and No. Y202043729.
Conflict-of-interest statement: All the authors report no conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Yu Chen, PhD, Department of Respiration, Affiliated Hospital of Jiaxing University, No. 1882 South Zhonghuan Road, Jiaxing 314000, Zhejiang Province, China. 00135116@zjxu.edu.cn
Received: July 27, 2021 Peer-review started: July 27, 2021 First decision: October 22, 2021 Revised: November 4, 2021 Accepted: January 29, 2022 Article in press: January 29, 2022 Published online: March 16, 2022
ARTICLE HIGHLIGHTS
Research background
Patients with moderate to severe coronavirus disease 2019 (COVID-19) infection often have severe acute respiratory distress syndrome, with a poor prognosis, limited treatment options, and high mortality. Extracorporeal membrane oxygenation (ECMO) has been proven to have the advantages of improving symptoms and reducing mortality in previous studies. However, existing studies lack strong evidence and disagreement whether ECMO can reduce the mortality of patients with moderate to severe COVID-19 infection. This article intends to summarize the mortality of COVID-19 patients treated with ECMO in order to evaluate the efficacy of ECMO in COVID-19 patients.
Research motivation
To summarize the mortality and comorbidities of COVID-19 patients treated with ECMO, to evaluate the efficacy and adverse reactions of ECMO inCOVID-19 patients, and to clarify the effectiveness of ECMO treatment, in order to provide a basis for future treatment options for patients with moderate to severe COVID-19.
Research objectives
To evaluate the efficacy and adverse reactions of ECMO inCOVID-19 patients.
Research methods
This research was conducted through the method of meta-analysis. A random effects model was adopted to assess the mortality of COVID-19 patients treated with ECMO.
Research results
The mortality rate of COVID-19 patients treated with ECMO was 31%, which was lower than the mortality rates of severe COVID-19 patients in previous studies, suggesting that ECMO treatment can reduce the mortality rate of severe COVID-19 patients. Previous studies have not yet given clear answers to when ECMO should be used and the duration of ECMO treatment.
Research conclusions
ECMO may be a feasible and effective treatment for COVID-19 patients.
Research perspectives
Prospective, large-sample, multi-center studies are needed to have a more comprehensive understanding of the effectiveness and safety of ECMO treatment.
