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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Epidemiological features and dynamic changes in blood biochemical indices for COVID-19 patients in Hebi
Xiao-Bo Nie, Bao-Sheng Shi, Lin Zhang, Wei-Li Niu, Ting Xue, Lan-Qing Li, Xiao-Yun Wei, Yan-Dong Wang, Wei-Dong Chen, Rui-Fang Hou
Xiao-Bo Nie, Ting Xue, Lan-Qing Li, Xiao-Yun Wei, Wei-Dong Chen, Key Laboratory of Receptors-Mediated Gene Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, Henan Province, China
Xiao-Bo Nie, Wei-Dong Chen, Department of Infectious Diseases,The People’s Hospital of Hebi, Hebi 458031, Henan Province, China
Bao-Sheng Shi, Lin Zhang, Wei-Li Niu, Department of Infectious Diseases, The Third People’s Hospital of Hebi, Hebi 458031, Henan Province, China
Yan-Dong Wang, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, Beijing Province, China
Rui-Fang Hou, Department of Infectious Diseases, The People’s Hospital of Hebi, Henan University, Hebi Key Laboratory of Liver Disease, Hebi 458031, Henan Province, China
Author contributions: Nie XB and Hou RF designed the research study; Shi BS, Zhang L, Niu WL, Xue T, Li LQ and Wei XY performed the research; Wang YD and Chen WD contributed analytic tools; Nie XB analyzed the data and wrote the manuscript; Hou RF revised the manuscript; all authors have read and approve the final manuscript.
Institutional review board statement: The study was reviewed and approved by the (Ethics Committee of People’s Hospital of Hebi) Institutional Review Board (Approval No. 2020004).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: (Nie XB, Xue T, Li LQ, Wei XY, Wei-Dong Chen) are employees of (Key Laboratory of Receptors-Mediated Gene Regulation, School of Basic Medical Sciences, Henan University). Hou RF is an employee of (Hebi Key Laboratory of Liver Disease, The People’s Hospital of Hebi, Henan University). (Shi BS, Zhang L, Niu WL) are employees of (The Third People’s Hospital of Hebi). Wang YD is an employee of (State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology). The authors declare that they have no conflicts of interest to disclose.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at dr_rfhou@126.com. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Rui-Fang Hou, Doctor, MD, Chairman, Doctor, Department of Infectious Diseases, The People’s Hospital of Hebi, Henan University, Hebi Key Laboratory of Liver Disease, Jiuzhou Street, Qibin District, Hebi 458031, Henan Province, China. dr_rfhou@126.com
Received: July 16, 2021
Peer-review started: July 16, 2021
First decision: October 16, 2021
Revised: October 20, 2021
Accepted: January 19, 2022
Article in press: January 19, 2022
Published online: March 16, 2022
ARTICLE HIGHLIGHTS
Research background
There are no studies on the dynamic changes of biochemical indices of patients with coronavirus disease 2019 (COVID-19) at admission, upon hospitalization and before discharge.
Research motivation
The epidemiological features and dynamic changes in blood biochemical indices for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients in Hebi, a representative city with a large floating population in North China, have not been well characterized.
Research objectives
This retrospective study aimed to analyze the data of patients with COVID-19 at admission, upon hospitalization and before discharge in order to clarify the epidemiological features and dynamic changes in blood biochemical indices of this disease.
Research methods
All available medical information, especially the laboratory data, was collected from 16 cases of laboratory-confirmed COVID-19 infection at admission, upon hospitalization and before discharge.
Research results
Fever and fatigue were the common symptoms of COVID-19 infection. Leukopenia, eosinopenia, decreased percentage of eosinophils, elevated high sensitivity C-reactive protein and fibrinogen levels, abnormal liver and renal function were valuable biochemical indices for patients with COVID-19. Aggravated liver dysfunction could be detected in most patients during treatment.
Research conclusions
Patients with COVID-19 have certain common symptoms at admission and dynamic changes in blood biochemical indices at admission, upon hospitalization and before discharge. Dynamic monitoring of blood biochemical indices can be beneficial to identify and predict the response of patients to various treatment modalities.
Research perspectives
Further investigations on stricter experimental design, larger samples and complete data collection are required to confirm whether the findings of this study could be applied on a broader scale.
