Observational Study
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World J Clin Cases. Feb 16, 2022; 10(5): 1548-1556
Published online Feb 16, 2022. doi: 10.12998/wjcc.v10.i5.1548
Correlation of myopia onset and progression with corneal biomechanical parameters in children
Li-Li Lu, Xiao-Juan Hu, Yan Yang, Shen Xu, Shi-Yong Yang, Cui-Yu Zhang, Qing-Ya Zhao
Li-Li Lu, Xiao-Juan Hu, Yan Yang, Shen Xu, Shi-Yong Yang, Cui-Yu Zhang, Qing-Ya Zhao, Department of Ophthalmology, Cangzhou Aier Eye Hospital, Cangzhou 061000, Hebei Province, China
Author contributions: Lu LL contributed to study conception, design, and writing of the article; Hu XJ, Yang Y contributed to collection of clinical data; Xu S, Yang SY contributed to data acquisition, data analysis, and interpretation; Zhang CY, Zhao QY contributed to editing, reviewing, and final approval of the article.
Institutional review board statement: This study was approved by the Cangzhou Aier Eye Hospital Ethics Committee.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that there is no conflict of interest to disclose.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Li Lu, MBChB, Attending Doctor, Department of Ophthalmology, Cangzhou Aier Eye Hospital, No. 35 Huanghe West Road, Yongan South Avenue, Yunhe District, Cangzhou 061000, Hebei Province, China. lili5lu@163.com
Received: October 15, 2021
Peer-review started: October 15, 2021
First decision: December 1, 2021
Revised: December 15, 2021
Accepted: December 31, 2021
Article in press: December 31, 2021
Published online: February 16, 2022
Processing time: 118 Days and 20.1 Hours
ARTICLE HIGHLIGHTS
Research background

Patients with myopia, especially those with high myopia, are much more likely to have serious complications such as retinal detachment and open-angle glaucoma than normal patients. High myopia may have a degenerative disorder, including cornea, sclera, choroid, optic disc, vitreous, macula, and peripheral retina.

Research motivation

The increasingly high incidents of myopia in children and the association with multiple corneal biomechanical parameters in local community and worldwide.

Research objectives

This study is to determine the change of corneal biomechanical parameters after onset and progression of myopia.

Research methods

A total of 207 myopic subjects were enrolled according to local clinic criteria and one-way ANOVA test was applied to determine whether there is statistical evidence between different general ocular measurement parameters.

Research results

There is a correlation between the development of myopia and various corneal biomechanical parameters in children.

Research conclusions

There are positive and negative correlations between myopia and general eye measurement parameters, corneal biomechanical parameters and other multiple parameters.

Research perspectives

Corneal ophthalmometric parameters and biomechanical properties including multiple baselines may be able to predict the development of myopia.