Prospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 26, 2022; 10(30): 10939-10955
Published online Oct 26, 2022. doi: 10.12998/wjcc.v10.i30.10939
Patient reported outcome measures in anterior cruciate ligament rupture and reconstruction: The significance of outcome score prediction
Oday Al-Dadah, Lee Shepstone, Simon T Donell
Oday Al-Dadah, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle-upon-Tyne NE2 4HH, Tyne and Wear, United Kingdom
Oday Al-Dadah, Department of Trauma and Orthopaedic Surgery, South Tyneside District Hospital, South Shields NE34 0PL, Tyne and Wear, United Kingdom
Lee Shepstone, Department of Medical Statistics, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, Norfolk, United Kingdom
Simon T Donell, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, Norfolk, United Kingdom
Author contributions: Al-Dadah O made substantial contributions to conception and design of the study and acquisition of data; He also performed the analysis and interpretation of data; Has been involved in drafting the manuscript and revising it critically for important intellectual content; Has given final approval of the version to be published; Shepstone L made substantial contributions to conception and design of the study; He also made substantial contributions to the analysis and interpretation of data; Has been involved in drafting the manuscript and revising it critically for important intellectual content; Has given final approval of the version to be published; Donell ST made substantial contributions to conception and design of the study; He also made substantial contributions to the interpretation of data; Has been involved in drafting the manuscript and revising it critically for important intellectual content; Has given final approval of the version to be published.
Institutional review board statement: Full approval was received for the study from the Research Ethics Committee and the Research Governance Committee. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee [East Norfolk and Waveney Research Governance Committee, United Kingdom (ID 116/07/07)] and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Clinical trial registration statement: This study was not registered on any trial registry.
Informed consent statement: All study participants, or their legal guardian, provided written consent prior to study enrollment.
Conflict-of-interest statement: All authors declare that they have no conflict of interest.
Data sharing statement: The data underlying this article cannot be shared publicly due to the privacy of individuals that participated in the study and in keeping with the United Kingdom General Data Protection Regulation and also the host study organization’s patient confidentiality guidelines.
CONSORT 2010 statement: The authors have read the CONSORT Statement—checklist of items, and the manuscript was prepared and revised according to the CONSORT Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Oday Al-Dadah, FRCS, MBChB, MD, Senior Lecturer, Surgeon, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle-upon-Tyne NE2 4HH, Tyne and Wear, United Kingdom. oday.al-dadah@newcastle.ac.uk
Received: February 13, 2022
Peer-review started: February 13, 2022
First decision: June 15, 2022
Revised: July 5, 2022
Accepted: September 19, 2022
Article in press: September 19, 2022
Published online: October 26, 2022
Processing time: 249 Days and 5.2 Hours
ARTICLE HIGHLIGHTS
Research background

Many different types of clinical outcome scores exist regarding the anterior cruciate ligament (ACL).

Research motivation

To evaluate how the commonly used patient reported outcome scores (PROMs) differ from each other in the context of ACL injuries.

Research objectives

To develop mathematical formulae which will allow the results of one score to be calculated from the results of the other.

Research methods

PROM data was collected from patients before and after ACL reconstruction surgery and statistically analyzed using correlation and regression tests.

Research results

Statistically significant results for both the correlation and regression analyses were found between most of the outcome scores and were generally stronger following surgery.

Research conclusions

The mathematical formulae produced from this study can be used to predict the outcome of one knee score when the results of the other are known.

Research perspectives

These mathematical formulae can facilitate the conduct of systematic reviews and meta-analysis in studies relating to ACL surgery by allowing the pooling of substantially more data.