Published online Jan 21, 2022. doi: 10.12998/wjcc.v10.i3.870
Peer-review started: August 18, 2021
First decision: October 3, 2021
Revised: October 19, 2021
Accepted: December 22, 2021
Article in press: December 22, 2021
Published online: January 21, 2022
Processing time: 150 Days and 11.2 Hours
Gastric cancer deaths in China account for more than 40% of the global total of gastric cancer deaths in the same period. Reducing cancer-related mortality and improving quality of life is one of the current research focuses, and the number of lymph nodes dissected was an independent factor affecting postoperative staging of gastric cancer. There are still no specific guidelines for when preoperative labeling should be performed, based on many previous works, this work extended the time of preoperative submucosal tracer injection, and discuss whether it is effective.
In order to help surgeons to more lymph node dissection, and improve postoperative pathological staging; At the same time, whether the preoperative labeling time has a certain influence on the number of lymph node dissection was studied.
To study the influence of preoperative carbon nanoparticle labeling combined with radical gastrectomy on the number of dissected lymph nodes and postoperative anti-tumor treatment effect, and to study the influence of preoperative labeling time on the number of dissected lymph nodes.
Retrospective analysis study was performed, all patients were randomly divided into experimental group (preoperative injection of carbon-nano group) and control group (preoperative injection of carbon-nano group) according to the principle of randomization; In the experimental group, according to the different groups of preoperative labeling time, the differences between the groups were studied.
The average number of dissected lymph nodes in the experimental group [34.95 ± 4.81/case in the laparoscopic total gastrectomy (LTG) group; 32.65 ± 3.82/case in the laparoscopic subtotal gastrectomy (LSG) group] was higher than that in the control group (31.90 ± 4.47/case in the LTG group; 30.88 ± 2.69/case in the LSG group, P < 0.05). In comparisons within the experimental group, the experimental results (number of lymph node dissections, number of black-staining lymph nodes) of the nano-carbon labeling group 2 and 1 d before surgery were better than those of the labeling group on the day before surgery (P < 0.05).
(1) Nano-carbon labeling has a good guiding effect on lymph node dissection during laparoscopic gastric cancer, and it is safe and effective; and (2) Compared with the control group, submucosal injection of a carbon tracer in the experimental group at a certain time before surgery can significantly improve the lymph node detection rate (P < 0.05), which is conducive to pathological staging and follow-up anti-tumor comprehensive treatment.
Gastric cancer is the fifth most common cancer in the world, redical operation is still the preferred treatment method for advanced gastric cancer, postoperative lymph node detection rate is one of the major factors affecting PN staging of lymph node metastasis after radical gastrectomy, In order to help the surgeon correctly distinguish the normal tissue from the lymph nodes and dissect lymph nodes as much as possible, endoscopic injection of carbon nanoparticles was selected.