Published online Aug 26, 2022. doi: 10.12998/wjcc.v10.i24.8587
Peer-review started: September 10, 2021
First decision: January 18, 2022
Revised: January 25, 2022
Accepted: July 19, 2022
Article in press: July 19, 2022
Published online: August 26, 2022
The value of multiparameter diffusion-weighted imaging (DWI) in quantitative evaluation of thyroid nodule has not been clarified.
It provides a new idea for differentiating benign and malignant thyroid results by using multiparametric diffusion-weighted imaging.
To provide a non-invasive diagnostic means for differentiating benign and malignant thyroid nodules by multiparametric DWI, furthermore, we elucidated which parameters have diagnostic function in differentiating the nature of thyroid nodule
We obtained Multiple DWI parameters by patients who underwent multi-b value diffusion-weighted imaging of the thyroid,then the data of benign and malignant nodules were obtained and analyzed.
Malignant lesions displayed lower diffusion parameters including apparent diffusion coefficient (ADC), the true diffusion coefficient (D), the perfusion fraction (f), the distributed diffusion coefficient (DDC), the intravoxel water diffusion heterogeneity (α) and kurtosis model-derived ADC (Dapp), and higher apparent diffusional kurtosis (Kapp) than benign entities (all P < 0.01). The area under the ROC curve (AUC) of the ADC(0 and 1000) was significantly higher than the AUC of D*, f and α (all P < 0.05) for differentiating benign from malignant lesions.
The metrics including D, DDC, Dapp and Kapp provide additional information with similar diagnostic performance of ADC, combination of these metrics may contribute to differentiate benign and malignant thyroid nodules.
In the future, multiple parameters of magnetic resonance diffusion can be used to accurately distinguish benign and malignant thyroid nodules.