Shi S, Gan L, Jin CN, Liu RF. Effects of propofol combined with lidocaine on hemodynamics, serum adrenocorticotropic hormone, interleukin-6, and cortisol in children. World J Clin Cases 2022; 10(24): 8506-8513 [PMID: 36157832 DOI: 10.12998/wjcc.v10.i24.8506]
Corresponding Author of This Article
Rong-Fang Liu, MD, Attending Doctor, Department of Anesthesiology, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding 071000, Hebei Province, China. liurf2021@163.com
Research Domain of This Article
Anesthesiology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Aug 26, 2022; 10(24): 8506-8513 Published online Aug 26, 2022. doi: 10.12998/wjcc.v10.i24.8506
Effects of propofol combined with lidocaine on hemodynamics, serum adrenocorticotropic hormone, interleukin-6, and cortisol in children
Song Shi, Lu Gan, Chun-Nv Jin, Rong-Fang Liu
Song Shi, Lu Gan, Rong-Fang Liu, Department of Anesthesiology, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China
Chun-Nv Jin, Department of Anesthesiology, Baoding Maternal and Child Health Hospital, Baoding 071000, Hebei Province, China
Author contributions: Shi S, Lu G and Liu RF designed this retrospective study and wrote the paper; Shi S and Liu RF contributed equally to this study, and considered as so-first authors; Shi S, Lu G, Liu RF and Jin CN were responsible for sorting the data.
Institutional review board statement: This study was reviewed and approved by the Affiliated Hospital of Hebei University.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rong-Fang Liu, MD, Attending Doctor, Department of Anesthesiology, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding 071000, Hebei Province, China. liurf2021@163.com
Received: January 17, 2022 Peer-review started: January 17, 2022 First decision: March 3, 2022 Revised: March 17, 2022 Accepted: July 18, 2022 Article in press: July 18, 2022 Published online: August 26, 2022
ARTICLE HIGHLIGHTS
Research background
Pediatric abdominal surgery is a common type of pediatric surgery. Due to the poor tolerance of children and prone to crying and bad emotions such as crying, general anesthesia is mostly selected in the clinical operation. Therefore, reasonable choice of anesthetic drugs is of great significance to ensure the effect of surgery in children.
Research motivation
In this study, the effect of propofol compound lidocaine-assisted anesthesia in pediatric surgery was observed.
Research objectives
This study aimed to explore the clinical value of propofol combined with lidocaine-assisted anesthesia in pediatric surgery.
Research methods
A total of 120 children who underwent abdominal surgery selected and divided into groups A and B using the random number table method, with 60 patients in each group. Group B received ketamine for anesthesia, while group A received ketamine, propofol, and lidocaine. The pre- and postoperative heart rate; mean arterial pressure; arterial oxygen saturation; serum adrenocorticotropic hormone, interleukin-6, and cortisol levels were compared between the two groups.
Research results
The anesthetic effect of propofol combined with lidocaine and ketamine in pediatric surgery is better than that of ketamine alone, and had less influence on hemodynamics and stress response indices, lower incidence of restlessness in the recovery period, and lower incidence of adverse reactions.
Research conclusions
The anesthetic effect of propofol combined with lidocaine and ketamine in pediatric surgery was better than that of ketamine alone.
Research perspectives
This study explored the clinical value of propofol combined with lidocaine-assisted anesthesia in pediatric surgery.
