Ma B, Huang XT, Zou GJ, Hou WY, Du XH. Relationship between Ki-67 and CD44 expression and microvascular formation in gastric stromal tumor tissues. World J Clin Cases 2022; 10(2): 469-476 [PMID: 35097071 DOI: 10.12998/wjcc.v10.i2.469]
Corresponding Author of This Article
Xiao-Hui Du, MD, Chief Physician, Department of General Surgery, The PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. duxiaohui301@sina.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jan 14, 2022; 10(2): 469-476 Published online Jan 14, 2022. doi: 10.12998/wjcc.v10.i2.469
Relationship between Ki-67 and CD44 expression and microvascular formation in gastric stromal tumor tissues
Bing Ma, Xiao-Tian Huang, Gui-Jun Zou, Wen-Yu Hou, Xiao-Hui Du
Bing Ma, Xiao-Tian Huang, Gui-Jun Zou, Wen-Yu Hou, Xiao-Hui Du, Department of General Surgery, The PLA General Hospital, Beijing 100853, China
Author contributions: Ma B and Du XH performed the research; Huang XT contributed new reagents and analytic tools; Zou GJ and Hou WY analyzed the data and wrote the manuscript; all authors have read and approve the final manuscript.
Institutional review board statement: The study was reviewed and approved by the PLA General Hospital Institutional Review Board (Approval No. 20210321).
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: None conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Hui Du, MD, Chief Physician, Department of General Surgery, The PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. duxiaohui301@sina.com
Received: August 26, 2021 Peer-review started: August 26, 2021 First decision: September 29, 2021 Revised: October 8, 2021 Accepted: November 29, 2021 Article in press: November 29, 2021 Published online: January 14, 2022
ARTICLE HIGHLIGHTS
Research background
The incidence of gastric stromal tumors (GSTs) is increasing. The severity of a GST is often evaluated by factors such as risk classification, tumor size, and mitotic figures. However, these indicators are not very accurate.
Research motivation
Few studies have addressed the relationship between GSTs and microvessel density.
Research objectives
In this study, the authors aimed to explore the relationship between Ki-67 and CD44 expression in GST tissues and microangiogenesis.
Research methods
Tissue specimens of 86 cases of GSTs were selected for this study. All cases met the inclusion and exclusion criteria.
Research results
High pathological risk grades, increased mitotic figures, and positive expression of the CD44 protein in patients with GSTs were independent risk factors for poor prognosis.
Research conclusions
The expression of Ki-67 and CD44 in GSTs has certain relationships with the tumor risk grade and mitotic changes.
Research perspectives
A deeper study with a larger sample size is needed to confirm this finding.
