Huang YX, Xu ZM, Zhao L, Cao Y, Chen Y, Qiu YG, Liu YM, Zhang PY, He JC, Li TC. Long-term outcomes of high-risk percutaneous coronary interventions under extracorporeal membrane oxygenation support: An observational study. World J Clin Cases 2022; 10(16): 5266-5274 [PMID: 35812664 DOI: 10.12998/wjcc.v10.i16.5266]
Corresponding Author of This Article
Tian-Chang Li, MD, PhD, Chief Physician, Department of Cardiology, Sixth Medical Center of Chinese People’s Liberation Army General Hospital, No. 6 Fucheng Road, Beijing 100048, China. itc909@163.com
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 6, 2022; 10(16): 5266-5274 Published online Jun 6, 2022. doi: 10.12998/wjcc.v10.i16.5266
Long-term outcomes of high-risk percutaneous coronary interventions under extracorporeal membrane oxygenation support: An observational study
Yi-Xiong Huang, Zheng-Ming Xu, Li Zhao, Yi Cao, Yu Chen, Yi-Gang Qiu, Ying-Ming Liu, Peng-Yu Zhang, Jiang-Chun He, Tian-Chang Li
Yi-Xiong Huang, Medical School of Chinese People’s Liberation Army, Beijing 100853, China
Yi-Xiong Huang, Zheng-Ming Xu, Li Zhao, Yi Cao, Yu Chen, Yi-Gang Qiu, Ying-Ming Liu, Peng-Yu Zhang, Jiang-Chun He, Tian-Chang Li, Department of Cardiology, Sixth Medical Center of Chinese People’s Liberation Army General Hospital, Beijing 100048, China
Author contributions: Huang YX, Chen Y, and Li TC designed the study; Huang YX drafted the manuscript; Cao Y, Qiu YG, Liu YM, and He JC revised it critically for important intellectual content; Xu ZM, Zhao L, and Zhang PY contributed to the analysis and interpretation of data; Li TC, the corresponding author of this manuscript, gave final approval of the manuscript submitted.
Institutional review board statement: The study was reviewed and approved by the Sixth Medical Center of PLA General Hospital Institutional Review Board (Beijing).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: Technical appendix, statistical code, and dataset are available from the corresponding author at itc909@163.com.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tian-Chang Li, MD, PhD, Chief Physician, Department of Cardiology, Sixth Medical Center of Chinese People’s Liberation Army General Hospital, No. 6 Fucheng Road, Beijing 100048, China. itc909@163.com
Received: August 2, 2021 Peer-review started: August 2, 2021 First decision: December 17, 2021 Revised: December 30, 2021 Accepted: April 2, 2022 Article in press: April 2, 2022 Published online: June 6, 2022 Processing time: 303 Days and 20 Hours
ARTICLE HIGHLIGHTS
Research background
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) offers hemodynamic support for patients who undergo high-risk percutaneous coronary intervention (PCI). However, long-term outcomes associated with VA-ECMO have not previously been studied.
Research motivation
High-risk PCI can result in hemodynamic instability during the perioperative period and is associated with poor outcomes. Hemodynamic support is crucial in patients undergoing high-risk PCI.
Research objectives
To investigate long-term outcomes in high-risk cases receiving PCI supported by VA-ECMO.
Research methods
Patients who received VA-ECMO-supported high-risk PCI were assessed. High-risk PCI was defined according to the patient’s hemodynamic status, clinical features, underlying diseases, and coronary anatomy/lesion complexities. The long-term outcomes comprising all-cause mortality, repeated cardiovascular diseases, and cardiac death were recorded.
Research results
Of 61 enrolled patients, 57 patients (93.4%) were successfully treated by VA-ECMO-supported PCI. The in-hospital mortality was 23.0%, and the overall survival was 45.9% with a median follow-up period of 38.6 (8.6-62.1) mo.
Research conclusions
VA-ECMO can be used as a support for patients undergoing high-risk PCI as it is related to favorable long-term patient survival.
Research perspectives
A large multicenter prospective trial is required to confirm the benefit and safety of VA-ECMO-supported high-risk PCI.
