Expert Consensus
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 26, 2021; 9(9): 2037-2046
Published online Mar 26, 2021. doi: 10.12998/wjcc.v9.i9.2037
Expert consensus of Chinese Association for the Study of Pain on the application of ozone therapy in pain medicine
Zhi-Gang Zhuang, Li-Juan Lu, Bao-Gan Peng, Ke Ma, Zhen-Yu Cai, Zhi-Jian Fu, Guang-Zhao Liu, Jin-Feng Liu, Wen-Tao Liu, Xiao-Hong Li, Tao Song, Da-Sheng Wu, Jing Yao, Peng Yao, Jian-She Yu, Yan-Qing Liu
Zhi-Gang Zhuang, Department of Algology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, Henan Province, China
Li-Juan Lu, Department of Algology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China
Bao-Gan Peng, Department of Orthopedics, The Third Medical Center, General Hospital of the Chinese People’s Liberation Army, Beijing 100039, China
Ke Ma, Department of Algology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200000, China
Zhen-Yu Cai, Department of Algology, The First Affiliated Hospital of Xiamen University, Xiamen 361005, Fujian Province, China
Zhi-Jian Fu, Department of Algology, Shandong Provincial Hospital, Jinan 250021, Shandong Province, China
Guang-Zhao Liu, Department of Algology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China
Jin-Feng Liu, Department of Algology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Wen-Tao Liu, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Xiao-Hong Li, Department of Algology, Foshan First People’s Hospital, Foshan 528000, Guangdong Province, China
Tao Song, Department of Algology, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Da-Sheng Wu, Department of Algology, Jilin Provincial People's Hospital, Changchun 130499, Jilin Province, China
Jing Yao, Department of Algology, The Affiliated Hospital of Guizhou Medical University, Guiyang 550025, Guizhou Province, China
Peng Yao, Department of Algology, Sheng Jing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Jian-She Yu, Department of Algology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia Autonomous Region, China
Yan-Qing Liu, Department of Algology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
Author contributions: Zhuang ZG, Lu LJ, Peng BG, Liu YQ and Liu WT drafted the section “Pharmacological Mechanisms;” Zhuang ZG, Liu YQ and Ma K drafted the section “Indications and contraindications;” Zhuang ZG, Lu LJ, Liu YQ, Liu GZ, Liu JF, Cai ZY and Fu ZJ drafted some other parts of the manuscript; Zhuang ZG, Lu LJ, Liu YQ, Li XH, Song T, Wu DS, Yao J, Yao P and Yu JS drafted the section “Prevention and treatment of adverse reactions and complications” and “Expert consensus statement;” All authors participated in the revision of the consensus.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Qing Liu, MD, Department of Algology, Beijing Tiantan Hospital, Capital Medical University, No. 119 Nansihuan Xi Road, Fengtai District, Beijing 100070, China. lyqttyy@126.com
Received: November 28, 2020
Peer-review started: November 28, 2020
First decision: December 21, 2020
Revised: January 15, 2021
Accepted: March 2, 2021
Article in press: March 2, 2021
Published online: March 26, 2021
Abstract

This consensus was compiled by first-line clinical experts in the field of pain medicine and was organized by the Chinese Association for the Study of Pain. To reach this consensus, we consulted a wide range of opinions and conducted in-depth discussions on the mechanism, indications, contraindications, operational specifications and adverse reactions of ozone iatrotechnique in the treatment of pain disorders. We also referred to related previous preclinical and clinical studies published in recent years worldwide. The purpose of this consensus is to standardize the rational application of ozone iatrotechnique in pain treatment, to improve its efficacy and safety and to reduce and prevent adverse reactions and complications in this process.

Keywords: Ozone iatrotechnique, Pain department, Expert consensus, Pain, Ozone, Guideline

Core Tip: We consulted a wide range of opinions and conducted in-depth discussions on the mechanism, indications, contraindications, operational specifications and adverse reactions of ozone iatrotechnique in the treatment of pain diseases. We also referred to the related previous preclinical and clinical studies published in recent years around the world. The purpose of this consensus is to standardize the rational application of ozone iatrotechnique in pain treatment, to improve its efficacy and safety and to reduce and prevent adverse reactions and complications in this process.