Moon DS, Yoon SH, Lee SI, Park SG, Na YS. Interstitial lung disease induced by the roots of Achyranthes japonica Nakai: Three case reports. World J Clin Cases 2021; 9(8): 2015-2021 [PMID: 33748255 DOI: 10.12998/wjcc.v9.i8.2015]
Corresponding Author of This Article
Yong-Sub Na, MD, Assistant Professor, Department of Pulmonology and Critical Care Medicine, Chosun University Hospital, 365 Pilmun-daero, Dong-gu, Gwangju 61453, South Korea. ebusters@chosun.ac.kr
Research Domain of This Article
Respiratory System
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Mar 16, 2021; 9(8): 2015-2021 Published online Mar 16, 2021. doi: 10.12998/wjcc.v9.i8.2015
Interstitial lung disease induced by the roots of Achyranthes japonica Nakai: Three case reports
Do-Sik Moon, Sung-Ho Yoon, Seung-Il Lee, Sang-Gon Park, Yong-Sub Na
Do-Sik Moon, Sung-Ho Yoon, Seung-Il Lee, Yong-Sub Na, Department of Pulmonology and Critical Care Medicine, Chosun University Hospital, Gwangju 61453, South Korea
Sang-Gon Park, Department of Internal Medicine, Hemato-Oncology, Chosun University Hospital, Gwangju 61453, South Korea
Author contributions: Na YS made the conceptualization; Moon DS, Na YS, Yoon SH investigated; Moon DS, Na YS drafted the manuscript; Na YS, Yoon SH, Lee SI, Park SG reviewed and edited; all authors have read and approved the manuscript.
Informed consent statement: This study was approved by the institutional review board of Chosun university hospital. (IRB Number: 2020-07-018) Informed written consent was obtained from the patients for publication of this case series and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong-Sub Na, MD, Assistant Professor, Department of Pulmonology and Critical Care Medicine, Chosun University Hospital, 365 Pilmun-daero, Dong-gu, Gwangju 61453, South Korea. ebusters@chosun.ac.kr
Received: December 10, 2020 Peer-review started: December 10, 2020 First decision: December 28, 2020 Revised: January 6, 2021 Accepted: January 28, 2021 Article in press: January 28, 2021 Published online: March 16, 2021
Abstract
BACKGROUND
The roots of Achyranthes japonica Nakai (AJN), called “Useul-puli,” has been traditionally used to control pain and improve dysfunction in osteoarthritis patients in South Korea.
CASE SUMMARY
We described 3 patients diagnosed with herbal medicine induced interstitial lung disease after consuming boiled the roots of AJN. They were referred to our hospital because of the modified Medical Research Council grade 4 dyspnea. Chest computed tomography showed bilateral ground-glass opacities with patchy consolidation. After treatment with systemic glucocorticoid therapy and discontinuation of the roots of AJN, their symptoms improved, and almost all ground-glass opacities and patchy consolidations on chest radiography and chest computed tomography resolved.
CONCLUSION
We present three cases of interstitial lung disease induced by the roots of AJN.
Core Tip: To the best of our knowledge, this is the first case series of interstitial lung disease induced by the roots of Achyranthes japonica Nakai (AJN). Further studies are required to understand the mechanism and evaluate the prevalence of interstitial lung disease induced by the roots of AJN.
