Sun J, Ma XS, Qu LM, Song XS. Subcutaneous panniculitis-like T-cell lymphoma invading central nervous system in long-term clinical remission with lenalidomide: A case report. World J Clin Cases 2021; 9(8): 1885-1892 [PMID: 33748238 DOI: 10.12998/wjcc.v9.i8.1885]
Corresponding Author of This Article
Xue-Song Song, MD, PhD, Professor, Department of Anesthesiology, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. songxuesongjlu@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Mar 16, 2021; 9(8): 1885-1892 Published online Mar 16, 2021. doi: 10.12998/wjcc.v9.i8.1885
Subcutaneous panniculitis-like T-cell lymphoma invading central nervous system in long-term clinical remission with lenalidomide: A case report
Jing Sun, Xiao-Shan Ma, Li-Mei Qu, Xue-Song Song
Jing Sun, Xue-Song Song, Department of Anesthesiology, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Xiao-Shan Ma, Department of Neurosurgery, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Li-Mei Qu, Department of Pathology, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Sun J and Ma XS wrote the manuscript; Qu LM provided the pathological information and contributed to diagnosis; Song XS were responsible for the revision of the manuscript for important intellectual content; All authors issued final approval for the version to be submitted.
Supported byWu Jieping Medical Foundation, No. 320.6750.18515.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xue-Song Song, MD, PhD, Professor, Department of Anesthesiology, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. songxuesongjlu@163.com
Received: September 23, 2020 Peer-review started: September 23, 2020 First decision: December 31, 2020 Revised: January 10, 2021 Accepted: January 25, 2021 Article in press: January 25, 2021 Published online: March 16, 2021 Processing time: 163 Days and 1.8 Hours
Abstract
BACKGROUND
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) involvement in the central nervous system (CNS) is particularly rare. SPTCL with CNS involvement has an exceedingly poor prognosis, and no optimum therapeutic method has been discovered. To the best of our knowledge, this is the first reported case of SPTCL invading the CNS achieving long-term remission with lenalidomide maintenance therapy.
CASE SUMMARY
A 63-year-old man diagnosed with SPTCL was admitted to the hospital with severe headache for 15 d after four cycles of chemotherapy. Subsequent to the treatment, the patient developed CNS involvement. Craniotomy biopsy was pathologically diagnosed as CNS T-cell lymphoma, and two courses of chemotherapy were performed postoperatively. Due to the intolerance of the side effects of chemotherapeutic drugs, the patient received lenalidomide instead. The magnetic resonance imaging of the head at the 8 mo follow-up indicated no signs of recurrence, and the vital signs were stable.
CONCLUSION
Lenalidomide deserves further investigation as a targeted drug for SPTCL cases involving the CNS.
Core Tip: Subcutaneous panniculitis-like T-cell lymphoma is a rare peripheral T-cell lymphoma that occurs primarily in the skin. We present a special case of central nervous system T-cell lymphoma secondary to subcutaneous panniculitis-like T-cell lymphoma. Lenalidomide deserves further investigation as a targeted drug for subcutaneous panniculitis-like T-cell lymphoma cases involving the central nervous system.
