Meng EY, Wang ZM, Lei B, Shang LH. Gastrointestinal symptoms as the first sign of chronic granulomatous disease in a neonate: A case report. World J Clin Cases 2021; 9(32): 9997-10005 [PMID: 34877342 DOI: 10.12998/wjcc.v9.i32.9997]
Corresponding Author of This Article
Li-Hong Shang, MD, Doctor, Division of Neonatology, The Third Affiliated Hospital of Zhengzhou University, No. 7 Kangfuqian Street, Zhengzhou 450052, Henan Province, China. shanglihong10@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Er-Yan Meng, Bing Lei, Li-Hong Shang, Division of Neonatology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Zi-Ming Wang, Chongqing Medical College, Chongqing 400016, China
Author contributions: Meng EY and Shang LH conceptualized and designed the study, drafted the initial manuscript, and reviewed and revised the manuscript. Wang ZM and Lei B collected data, carried out the initial analyses, and reviewed the manuscript; all authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.
Informed consent statement: Informed consent was obtained from all individual participants included in the study.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Hong Shang, MD, Doctor, Division of Neonatology, The Third Affiliated Hospital of Zhengzhou University, No. 7 Kangfuqian Street, Zhengzhou 450052, Henan Province, China. shanglihong10@163.com
Received: June 30, 2021 Peer-review started: June 30, 2021 First decision: July 26, 2021 Revised: July 27, 2021 Accepted: September 23, 2021 Article in press: September 30, 2021 Published online: November 16, 2021 Processing time: 132 Days and 14.5 Hours
Abstract
BACKGROUND
Chronic granulomatous disease (CGD) characterized by recurrent and severe bacterial and fungal infections is most common in childhood.
CASE SUMMARY
We reported a 24-d-old male infant who developed gastrointestinal symptoms as the first sign of CGD.
CONCLUSION
Gastrointestinal symptoms representing the first sign of CGD are very rare, and prompt diagnosis and treatment with broad-spectrum antibiotics were of crucial importance.
Core Tip: Most chronic granulomatous diseases (CGDs) present with life-threatening recurrent bacterial and fungal infections, usually diagnosed in childhood. We describe a newborn with CGD that initially showed gastrointestinal symptoms. CGD cases with gastrointestinal manifestations as the first sign are very rare. To the best of our knowledge, this might be the youngest case of confirmed CGD with gastrointestinal involvement.
