Fang Y, Yang Y, Li N, Zhang XL, Huang HF. Emerging role of long noncoding RNAs in recurrent hepatocellular carcinoma. World J Clin Cases 2021; 9(32): 9699-9710 [PMID: 34877309 DOI: 10.12998/wjcc.v9.i32.9699]
Corresponding Author of This Article
Han-Fei Huang, MD, Chief Doctor, Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, No. 295 Xichang Road, Kunming 650032, Yunnan Province, China. kmhhf@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Nov 16, 2021; 9(32): 9699-9710 Published online Nov 16, 2021. doi: 10.12998/wjcc.v9.i32.9699
Emerging role of long noncoding RNAs in recurrent hepatocellular carcinoma
Yuan Fang, Yang Yang, Na Li, Xiao-Li Zhang, Han-Fei Huang
Yuan Fang, Na Li, Han-Fei Huang, Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
Yang Yang, Department of Otorhinolaryngology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
Xiao-Li Zhang, Department of Gastrointestinal and Hernia Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
Author contributions: Fang Y and Yang Y contributed equally to this work and should be regarded as co-first authors; Huang HF contributed to the manuscript conceptualization; Fang Y and Yang Y drafted the original manuscript, surveyed the literature, and managed the data; Li N and Zhang XL reviewed and edited the full content of the manuscript; all authors have read and agreed to the published version of the manuscript.
Conflict-of-interest statement: The authors declare no conflict of interest for this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Han-Fei Huang, MD, Chief Doctor, Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, No. 295 Xichang Road, Kunming 650032, Yunnan Province, China. kmhhf@126.com
Received: April 18, 2021 Peer-review started: April 18, 2021 First decision: June 3, 2021 Revised: June 5, 2021 Accepted: September 8, 2021 Article in press: September 8, 2021 Published online: November 16, 2021 Processing time: 205 Days and 19.9 Hours
Abstract
Hepatocellular carcinoma (HCC) remains one of the most frequent types of liver cancer and is characterized by a high recurrence rate. Recent studies have proposed that long non-coding RNAs (lncRNAs) are potential biomarkers in several recurrent tumor types. It is now well understood that invasion, migration, and metastasis are important factors for tumor recurrence. Moreover, some of the known risk factors for HCC may affect the expression levels of several types of lncRNAs and thus affect the recurrence of liver cancer through lncRNA regulation. In this paper, we review the biological functions, molecular mechanisms, and roles of lncRNAs in HCC and summarize current knowledge about lncRNAs as potential biomarkers in recurrent HCC.
Core Tip: Hepatocellular carcinoma (HCC) is one of the most recurring malignant tumors in the world. Intrahepatic metastasis and multicenter occurrence are two ways of recurrence of HCC. Currently, a growing number of studies have shown that long non-coding RNAs (lncRNAs), regulators of human gene expression, are abnormally expressed and influence the development of HCC. So, we need to further understand the significance of lncRNAs in the clinical diagnosis and treatment of recurrent HCC and explore the regulatory mechanisms of lncRNAs in the occurrence and treatment of recurrent HCC.
