Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 26, 2021; 9(30): 9101-9107
Published online Oct 26, 2021. doi: 10.12998/wjcc.v9.i30.9101
Particular tumor of the pancreas: A case report
Ming-Hui Zhu, Chang-Fu Nie
Ming-Hui Zhu, Department of General Surgery, Zhengzhou People's Hospital, Zhengzhou 450008, Henan Province, China
Chang-Fu Nie, Department of Hepatopancreatobiliary Surgery, the Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, Henan Province, China
Author contributions: Zhu MH and Nie CF were the patient’s surgeons and had participated in the surgical treatment of the patient, review of articles, as well as collecting radiological and pathological data; Nie CF contributed to the revisioning and polishing of the paper; Both authors approved the final version.
Supported by Henan Science and Technology Research Project, No. 162102310045.
Informed consent statement: All studies in this article have passed ethical review, and relevant materials have been approved by the patient and authorized to use.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chang-Fu Nie, PhD, Chief Doctor, Department of Hepatopancreatobiliary Surgery, the Affiliated Cancer Hospital of Zhengzhou University, No. 127 Dongming Road, Zhengzhou 450008, Henan Province, China. zhuminghui258@163.com
Received: December 11, 2020
Peer-review started: December 11, 2020
First decision: January 17, 2021
Revised: January 31, 2021
Accepted: August 23, 2021
Article in press: August 23,2021
Published online: October 26, 2021
Abstract
BACKGROUND

Granular cell tumor (GCT) of the pancreas is a rare neurogenic tumor. The first case of pancreatic GCT was described in 1975, and up to now, only 7 cases have been reported.

CASE SUMMARY

A 53-year-old male had a pancreatic mass for 1 mo. He was not treated at the local hospital, but referred to Henan Tumor Hospital for surgery. Preoperative imaging revealed a 2.0 cm × 2.5 cm-sized mass located in the body of the pancreas. At the microscopic level, a large number of eosinophilic particles are present in the oval tumor cells. The immunohistochemistry of this tumor cell display CD56 (+), blood vessels CD34 (+), Ki-67 (+) < 10%, and S-100 (+).

CONCLUSION

GCT of the pancreas should be recognized as a preoperative differential diagnosis of pancreatic tumors. Surgical resection of the tumor should be attempted; however, GCT of the pancreas has a certain rate of tumor metastasis and recurrence. Therefore, GCT of the pancreas requires regular and long-term follow-up.

Keywords: Granular cell tumor, Pancreas, Diagnosis, Case report

Core Tip: Granular cell tumor (GCT) of the pancreas is a rare neurogenic tumor. We present a rare case of pancreatic GCT, which recovered successfully after surgical treatment. We reviewed 7 previous cases of the same tumor and conclude that most of the pancreatic GCTs are benign, but there is a potential malignancy. Surgery is an important treatment for this disease, and there is a certain rate of tumor metastasis and recurrence after surgery, so regular reexamination should be insisted on.